Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

BACKGROUND: Mutations in the fused in sarcoma (FUS) gene have been linked to amyotrophic lateral sclerosis (ALS). ALS patients with FUS mutations exhibit neuronal cytoplasmic mislocalization of the mutant FUS protein. ALS patients’ fibroblasts or induced pluripotent stem cell (iPSC)-derived neurons...

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Detalles Bibliográficos
Autores principales: Lim, Su Min, Choi, Won Jun, Oh, Ki-Wook, Xue, Yuanchao, Choi, Ji Young, Kim, Sung Hoon, Nahm, Minyeop, Kim, Young-Eun, Lee, Jinhyuk, Noh, Min-Young, Lee, Seungbok, Hwang, Sejin, Ki, Chang-Seok, Fu, Xiang-Dong, Kim, Seung Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722778/
https://www.ncbi.nlm.nih.gov/pubmed/26795035
http://dx.doi.org/10.1186/s13024-016-0075-6

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