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A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections
Luliconazole is a novel imidazole derivative, which has demonstrated in vitro efficacy against dermatophytes and Candida. The results from Phase III trials show that luliconazole 1% cream applied once daily for 2 weeks successfully resolved the clinical signs and symptoms as well as eradicated the p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723097/ https://www.ncbi.nlm.nih.gov/pubmed/26848272 http://dx.doi.org/10.2147/IDR.S61998 |
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author | Gupta, Aditya K Daigle, Deanne |
author_facet | Gupta, Aditya K Daigle, Deanne |
author_sort | Gupta, Aditya K |
collection | PubMed |
description | Luliconazole is a novel imidazole derivative, which has demonstrated in vitro efficacy against dermatophytes and Candida. The results from Phase III trials show that luliconazole 1% cream applied once daily for 2 weeks successfully resolved the clinical signs and symptoms as well as eradicated the pathologic fungi, which cause tinea pedis. A 1-week treatment with luliconazole 1% cream also produced favorable clinical and mycological results in clinical trials for tinea corporis and tinea cruris. Across trials, adverse events consisted mainly of localized reactions following application. The development of a new antifungal agent is timely due to mounting resistance among existing treatments. Because luliconazole requires a short duration of treatment, it may assist in reducing disease recurrence as a result of patient nonadherence. |
format | Online Article Text |
id | pubmed-4723097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47230972016-02-04 A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections Gupta, Aditya K Daigle, Deanne Infect Drug Resist Review Luliconazole is a novel imidazole derivative, which has demonstrated in vitro efficacy against dermatophytes and Candida. The results from Phase III trials show that luliconazole 1% cream applied once daily for 2 weeks successfully resolved the clinical signs and symptoms as well as eradicated the pathologic fungi, which cause tinea pedis. A 1-week treatment with luliconazole 1% cream also produced favorable clinical and mycological results in clinical trials for tinea corporis and tinea cruris. Across trials, adverse events consisted mainly of localized reactions following application. The development of a new antifungal agent is timely due to mounting resistance among existing treatments. Because luliconazole requires a short duration of treatment, it may assist in reducing disease recurrence as a result of patient nonadherence. Dove Medical Press 2016-01-18 /pmc/articles/PMC4723097/ /pubmed/26848272 http://dx.doi.org/10.2147/IDR.S61998 Text en © 2016 Gupta and Daigle. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed |
spellingShingle | Review Gupta, Aditya K Daigle, Deanne A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title | A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title_full | A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title_fullStr | A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title_full_unstemmed | A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title_short | A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
title_sort | critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723097/ https://www.ncbi.nlm.nih.gov/pubmed/26848272 http://dx.doi.org/10.2147/IDR.S61998 |
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