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A local renal renin–angiotensin system activation via renal uptake of prorenin and angiotensinogen in diabetic rats
The mechanism of activation of local renal renin–angiotensin system (RAS) has not been clarified in diabetes mellitus (DM). We hypothesized that the local renal RAS will be activated via increased glomerular filtration and tubular uptake of prorenin and angiotensinogen in diabetic kidney with microa...
Autores principales: | Tojo, Akihiro, Kinugasa, Satoshi, Fujita, Toshiro, Wilcox, Christopher S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723098/ https://www.ncbi.nlm.nih.gov/pubmed/26848273 http://dx.doi.org/10.2147/DMSO.S91245 |
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