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Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device

BACKGROUND: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape. MATERIAL AND METHODS: VX-2 tumor was used for the induction of exper...

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Autores principales: Proschek, D., Tonak, M., Zangos, S., Mack, M.G., Kurth, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723322/
https://www.ncbi.nlm.nih.gov/pubmed/26909257
http://dx.doi.org/10.1016/j.jbo.2012.07.001
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author Proschek, D.
Tonak, M.
Zangos, S.
Mack, M.G.
Kurth, A.A.
author_facet Proschek, D.
Tonak, M.
Zangos, S.
Mack, M.G.
Kurth, A.A.
author_sort Proschek, D.
collection PubMed
description BACKGROUND: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape. MATERIAL AND METHODS: VX-2 tumor was used for the induction of experimental bone metastases in the femur of six New Zealand white rabbits. X-ray imaging as well as CT and MRI scans before and after treatment was carried out. After detecting bone tumor, radiofrequency ablation was performed. The ablation instrument contained a 10 g bipolar, articulated extendable electrode and a proprietary generator with an impedance controlled algorithm. All bones and the soft tissue were examined histologically. RESULTS: All animals developed local bone tumor. Mean duration until first osteolytic lesions on CT-scans was 48±14 days. The mean lesion area was 26 mm(2). No systemic tumor spread was seen. 6 radiofrequency procedures were carried out with a mean application time of 6 min±2:30 and an average temperature in the region of effect of 55 °C±4. MRI imaging demonstrated an ablation zone of 23±6 mm around the electrode. Histopathology showed an extensive heat necrosis with no remaining tumor cells in the ablation area. CONCLUSION: Radiofrequency ablation is a quickly developing treatment option on the field of minimal invasive bone tumor therapy. The electrode enables an ablation adapted to size and shape of the metastases. Further clinical studies are necessary to test and enhance this radiofrequency system.
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spelling pubmed-47233222016-02-23 Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device Proschek, D. Tonak, M. Zangos, S. Mack, M.G. Kurth, A.A. J Bone Oncol Research Article BACKGROUND: Radiofrequency ablation is a minimal invasive therapy in the treatment of bone metastases. In this study we present a new ablation system enabling an ablation in multiple directions and with an adaptable size and shape. MATERIAL AND METHODS: VX-2 tumor was used for the induction of experimental bone metastases in the femur of six New Zealand white rabbits. X-ray imaging as well as CT and MRI scans before and after treatment was carried out. After detecting bone tumor, radiofrequency ablation was performed. The ablation instrument contained a 10 g bipolar, articulated extendable electrode and a proprietary generator with an impedance controlled algorithm. All bones and the soft tissue were examined histologically. RESULTS: All animals developed local bone tumor. Mean duration until first osteolytic lesions on CT-scans was 48±14 days. The mean lesion area was 26 mm(2). No systemic tumor spread was seen. 6 radiofrequency procedures were carried out with a mean application time of 6 min±2:30 and an average temperature in the region of effect of 55 °C±4. MRI imaging demonstrated an ablation zone of 23±6 mm around the electrode. Histopathology showed an extensive heat necrosis with no remaining tumor cells in the ablation area. CONCLUSION: Radiofrequency ablation is a quickly developing treatment option on the field of minimal invasive bone tumor therapy. The electrode enables an ablation adapted to size and shape of the metastases. Further clinical studies are necessary to test and enhance this radiofrequency system. Elsevier 2012-08-09 /pmc/articles/PMC4723322/ /pubmed/26909257 http://dx.doi.org/10.1016/j.jbo.2012.07.001 Text en © 2012 Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Proschek, D.
Tonak, M.
Zangos, S.
Mack, M.G.
Kurth, A.A.
Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title_full Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title_fullStr Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title_full_unstemmed Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title_short Radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
title_sort radiofrequency ablation in experimental bone metastases using a controlled and navigated ablation device
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723322/
https://www.ncbi.nlm.nih.gov/pubmed/26909257
http://dx.doi.org/10.1016/j.jbo.2012.07.001
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