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Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

The DNA polymerase and ribonuclease H (RNase H) activities of human immunodeficiency virus type 1 (HIV-1) are needed for the replication of the viral genome and are validated drug targets. However, there are no approved drugs inhibiting RNase H and the efficiency of DNA polymerase inhibitors can be...

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Detalles Bibliográficos
Autores principales:	Corona, Angela, Meleddu, Rita, Esposito, Francesca, Distinto, Simona, Bianco, Giulia, Masaoka, Takashi, Maccioni, Elias, Menéndez-Arias, Luis, Alcaro, Stefano, Le Grice, Stuart F. J., Tramontano, Enzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723341/ https://www.ncbi.nlm.nih.gov/pubmed/26800261 http://dx.doi.org/10.1371/journal.pone.0147225

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