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Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials

OBJECTIVE: Skeletal related events (SREs) are common in patients with bone metastases and lead to decreased quality of life and functional status. The definition of an SRE has evolved over the years and now excludes hypercalcemia of malignancy due to its low incidence. The purpose of this review was...

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Autores principales: Poon, Michael, Zeng, Liang, Zhang, Liying, Popovic, Marko, Chow, Ronald, Lam, Henry, Bedard, Gillian, Emmenegger, Urban, Simmons, Christine, Chow, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723343/
https://www.ncbi.nlm.nih.gov/pubmed/26909260
http://dx.doi.org/10.1016/j.jbo.2012.10.001
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author Poon, Michael
Zeng, Liang
Zhang, Liying
Popovic, Marko
Chow, Ronald
Lam, Henry
Bedard, Gillian
Emmenegger, Urban
Simmons, Christine
Chow, Edward
author_facet Poon, Michael
Zeng, Liang
Zhang, Liying
Popovic, Marko
Chow, Ronald
Lam, Henry
Bedard, Gillian
Emmenegger, Urban
Simmons, Christine
Chow, Edward
author_sort Poon, Michael
collection PubMed
description OBJECTIVE: Skeletal related events (SREs) are common in patients with bone metastases and lead to decreased quality of life and functional status. The definition of an SRE has evolved over the years and now excludes hypercalcemia of malignancy due to its low incidence. The purpose of this review was to investigate if advances in bone-targeted therapies have decreased skeletal morbidity rates (SMR) over time. METHODS: A literature search was conducted in several databases to identify phase III results from bone-targeted therapy trials from 1980 through September 2011. Graphs were created to document the trends of the natural log of SMR over the mean time of enrolment for all placebo and intervention arms. Statistical hypothesis testing was employed to account for confounding factors. RESULTS: A total of 14 studies were identified which reported the SMR from phase III trials from 1990 to 2007. A statistically significant downward trend was observed in the placebo arms of trials over time; a similar trend was seen in all intervention arms. In a direct comparison of intervention against placebo arms, it was found that there was a significant decreasing time trend (p<0.0001) and a significant departure in SMR from placebo to intervention arms (p=0.0348). These results were seen even after accounting for the confounding factors of histology and differences in drugs. CONCLUSION: The decrease in SMR over time may not only be a result of advancements with bone targeted agents, but also due to better management and awareness of events associated with bone metastases.
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spelling pubmed-47233432016-02-23 Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials Poon, Michael Zeng, Liang Zhang, Liying Popovic, Marko Chow, Ronald Lam, Henry Bedard, Gillian Emmenegger, Urban Simmons, Christine Chow, Edward J Bone Oncol Research Article OBJECTIVE: Skeletal related events (SREs) are common in patients with bone metastases and lead to decreased quality of life and functional status. The definition of an SRE has evolved over the years and now excludes hypercalcemia of malignancy due to its low incidence. The purpose of this review was to investigate if advances in bone-targeted therapies have decreased skeletal morbidity rates (SMR) over time. METHODS: A literature search was conducted in several databases to identify phase III results from bone-targeted therapy trials from 1980 through September 2011. Graphs were created to document the trends of the natural log of SMR over the mean time of enrolment for all placebo and intervention arms. Statistical hypothesis testing was employed to account for confounding factors. RESULTS: A total of 14 studies were identified which reported the SMR from phase III trials from 1990 to 2007. A statistically significant downward trend was observed in the placebo arms of trials over time; a similar trend was seen in all intervention arms. In a direct comparison of intervention against placebo arms, it was found that there was a significant decreasing time trend (p<0.0001) and a significant departure in SMR from placebo to intervention arms (p=0.0348). These results were seen even after accounting for the confounding factors of histology and differences in drugs. CONCLUSION: The decrease in SMR over time may not only be a result of advancements with bone targeted agents, but also due to better management and awareness of events associated with bone metastases. Elsevier 2012-11-21 /pmc/articles/PMC4723343/ /pubmed/26909260 http://dx.doi.org/10.1016/j.jbo.2012.10.001 Text en © 2012 Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Poon, Michael
Zeng, Liang
Zhang, Liying
Popovic, Marko
Chow, Ronald
Lam, Henry
Bedard, Gillian
Emmenegger, Urban
Simmons, Christine
Chow, Edward
Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title_full Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title_fullStr Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title_full_unstemmed Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title_short Skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
title_sort skeletal morbidity rates over time in patients with bone metastases from solid tumors reported in bone modifying agents randomised trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723343/
https://www.ncbi.nlm.nih.gov/pubmed/26909260
http://dx.doi.org/10.1016/j.jbo.2012.10.001
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