Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling

BACKGROUND: We applied a non-linear immunokinetic model to quantitatively compare absolute antibody uptake and turnover in subcutaneous LNCaP human prostate cancer (PCa) xenografts of two radiolabeled forms of the humanized anti-prostate-specific membrane antigen (PSMA) monoclonal antibody J591 ((12...

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Detalles Bibliográficos
Autores principales: Fung, Edward K., Cheal, Sarah M., Fareedy, Shoaib B., Punzalan, Blesida, Beylergil, Volkan, Amir, Jawaria, Chalasani, Sandhya, Weber, Wolfgang A., Spratt, Daniel E., Veach, Darren R., Bander, Neil H., Larson, Steven M., Zanzonico, Pat B., Osborne, Joseph R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723373/
https://www.ncbi.nlm.nih.gov/pubmed/26801327
http://dx.doi.org/10.1186/s13550-016-0164-0

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