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Targeting syndecan-1 in breast cancer inhibits osteoclast functions through up-regulation of osteoprotegerin
BACKGROUND: Breast cancer often metastasizes into bone and leads to osteolytic lesions. The underlying mechanisms, however, are complex and not fully understood. Syndecan-1 is a proteoglycan that has various functions relevant for tumor progression including cell–cell communication and cell–matrix i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723417/ https://www.ncbi.nlm.nih.gov/pubmed/26909290 http://dx.doi.org/10.1016/j.jbo.2013.11.001 |