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The functional diversity of retinal ganglion cells in the mouse

In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such “output channels” exist and what each encodes is an area of intense debate. In mouse, anatomical estimat...

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Autores principales: Baden, Tom, Berens, Philipp, Franke, Katrin, Rosón, Miroslav Román, Bethge, Matthias, Euler, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724341/
https://www.ncbi.nlm.nih.gov/pubmed/26735013
http://dx.doi.org/10.1038/nature16468
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author Baden, Tom
Berens, Philipp
Franke, Katrin
Rosón, Miroslav Román
Bethge, Matthias
Euler, Thomas
author_facet Baden, Tom
Berens, Philipp
Franke, Katrin
Rosón, Miroslav Román
Bethge, Matthias
Euler, Thomas
author_sort Baden, Tom
collection PubMed
description In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such “output channels” exist and what each encodes is an area of intense debate. In mouse, anatomical estimates range between 15–20 channels, and only a handful are functionally understood. Combining two-photon calcium imaging to obtain dense retinal recordings and unsupervised clustering of the resulting sample of >11,000 cells, we here show that the mouse retina harbours substantially more than 30 functional output channels. These include all known and several new ganglion cell types, as verified by genetic and anatomical criteria. Therefore, information channels from the mouse’s eye to the mouse’s brain are considerably more diverse than shown thus far by anatomical studies, suggesting an encoding strategy resembling that used in state-of-the-art artificial vision systems.
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spelling pubmed-47243412016-07-06 The functional diversity of retinal ganglion cells in the mouse Baden, Tom Berens, Philipp Franke, Katrin Rosón, Miroslav Román Bethge, Matthias Euler, Thomas Nature Article In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Each type encodes distinct visual features in parallel for transmission to the brain. How many such “output channels” exist and what each encodes is an area of intense debate. In mouse, anatomical estimates range between 15–20 channels, and only a handful are functionally understood. Combining two-photon calcium imaging to obtain dense retinal recordings and unsupervised clustering of the resulting sample of >11,000 cells, we here show that the mouse retina harbours substantially more than 30 functional output channels. These include all known and several new ganglion cell types, as verified by genetic and anatomical criteria. Therefore, information channels from the mouse’s eye to the mouse’s brain are considerably more diverse than shown thus far by anatomical studies, suggesting an encoding strategy resembling that used in state-of-the-art artificial vision systems. 2016-01-06 2016-01-21 /pmc/articles/PMC4724341/ /pubmed/26735013 http://dx.doi.org/10.1038/nature16468 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Baden, Tom
Berens, Philipp
Franke, Katrin
Rosón, Miroslav Román
Bethge, Matthias
Euler, Thomas
The functional diversity of retinal ganglion cells in the mouse
title The functional diversity of retinal ganglion cells in the mouse
title_full The functional diversity of retinal ganglion cells in the mouse
title_fullStr The functional diversity of retinal ganglion cells in the mouse
title_full_unstemmed The functional diversity of retinal ganglion cells in the mouse
title_short The functional diversity of retinal ganglion cells in the mouse
title_sort functional diversity of retinal ganglion cells in the mouse
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724341/
https://www.ncbi.nlm.nih.gov/pubmed/26735013
http://dx.doi.org/10.1038/nature16468
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