Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth

We previously identified CLEC14A as a tumour endothelial marker. Here we show CLEC14A is a regulator of sprouting angiogenesis in vitro and in vivo. Using a HUVEC spheroid sprouting assay we found CLEC14A to be a regulator of sprout initiation. Analysis of endothelial sprouting in aortic ring and in...

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Detalles Bibliográficos
Autores principales: PJ, Noy, P, Lodhia, K, Khan, X, Zhuang, DG, Ward, AR, Verissimo, A, Bacon, R, Bicknell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724939/
https://www.ncbi.nlm.nih.gov/pubmed/25745997
http://dx.doi.org/10.1038/onc.2015.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724939/
https://www.ncbi.nlm.nih.gov/pubmed/25745997
http://dx.doi.org/10.1038/onc.2015.34

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