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Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, the effe...

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Detalles Bibliográficos
Autores principales:	Mahiti, Macdonald, Toyoda, Mako, Jia, Xiaofei, Kuang, Xiaomei T., Mwimanzi, Francis, Mwimanzi, Philip, Walker, Bruce D., Xiong, Yong, Brumme, Zabrina L., Brockman, Mark A., Ueno, Takamasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724998/ https://www.ncbi.nlm.nih.gov/pubmed/26787826 http://dx.doi.org/10.1128/mBio.01516-15

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