Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy

Natural T-cell responses generally lack the potency to eradicate cancer. Enhanced affinity T-cell receptors (TCRs) provide an ideal approach to target cancer cells, with emerging clinical data showing significant promise. Nevertheless, the risk of off target reactivity remains a key concern, as exem...

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Detalles Bibliográficos
Autores principales: Raman, Marine C C, Rizkallah, Pierre J, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S, Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David K, Jakobsen, Bent K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725365/
https://www.ncbi.nlm.nih.gov/pubmed/26758806
http://dx.doi.org/10.1038/srep18851

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