Cargando…

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers

PURPOSE: To investigate the effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in humans. METHODS: Two independent, open-label, randomized, crossover studies were conducted in 24 (12 per study) healthy Chinese volunteers. In Study 1, each volunteer received a single oral dos...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yi-fan, Dai, Xiao-jian, Yang, Yong, Chen, Xiao-yan, Wang, Ting, Tang, Yun-biao, Tsai, Cheng-yuan, Chang, Li-wen, Chang, Yu-ting, Zhong, Da-fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725632/ https://www.ncbi.nlm.nih.gov/pubmed/26855561 http://dx.doi.org/10.2147/DDDT.S95934

Ejemplares similares

Effect of Probenecid on Pharmacokinetics and Tolerability of Olmesartan in Healthy Chinese Volunteers()
por: Li, Kun-Yan, et al.
Publicado: (2014)

Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia
por: Chen, Yuancheng, et al.
Publicado: (2023)

Coadministration of probenecid and cimetidine with mirogabalin in healthy subjects: A phase 1, randomized, open‐label, drug–drug interaction study
por: Tachibana, Masaya, et al.
Publicado: (2018)

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine
por: Wiebe, Sabrina T., et al.
Publicado: (2020)

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib
por: Hussaarts, Koen G. A. M., et al.
Publicado: (2020)

Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae
por: Li, Xin, et al.
Publicado: (2021)

Review of nemonoxacin with special focus on clinical development
por: Qin, Xiaohua, et al.
Publicado: (2014)

Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin
por: Kocsis, Bela, et al.
Publicado: (2016)

Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques
por: Chen, Mo, et al.
Publicado: (2013)

Efficacy and Safety of Nemonoxacin in Outpatients with Community-Acquired Pneumonia
por: Zhao, Bo, et al.
Publicado: (2020)

Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions
por: Britz, Hannah, et al.
Publicado: (2020)

Pharmacokinetic Drug-Drug Interaction and Responsible Mechanism between Memantine and Cimetidine
por: Choi, Young A., et al.
Publicado: (2018)

Pharmacokinetics of chloroquine and primaquine in healthy volunteers
por: Daher, André, et al.
Publicado: (2022)

Pharmacokinetics of a multicomponent herbal preparation in healthy Chinese and African volunteers
por: Alolga, Raphael N., et al.
Publicado: (2015)

Pharmacokinetic and pharmacodynamic modeling of oral mitiglinide on glucose lowering in healthy Chinese volunteers
por: Liu, Shijia, et al.
Publicado: (2017)

Pharmacokinetics of single- and multiple-dose roflumilast: an open-label, three-way crossover study in healthy Chinese volunteers
por: Huang, Jie, et al.
Publicado: (2018)

Pharmacokinetics of Cefozopran by Single and Multiple Intravenous Infusions in Healthy Chinese Volunteers
por: Wu, G. L., et al.
Publicado: (2015)

Single- and multiple-dose pharmacokinetics of inhaled indacaterol in healthy Chinese volunteers
por: Jiang, Ji, et al.
Publicado: (2014)

Evaluation of the safety, tolerability, and pharmacokinetics of RO7049389 in healthy Chinese volunteers
por: Wu, Xiaojie, et al.
Publicado: (2021)

Population pharmacokinetic analysis of transdermal granisetron in healthy Chinese and Caucasian volunteers
por: Li, Jiayu, et al.
Publicado: (2023)

Cimetidine and therapy of rodent tumours.
por: Hannant, D., et al.
Publicado: (1982)

Cimetidine in the Treatment of Herpes Zoster
por: Levy, D. W., et al.
Publicado: (1985)

Determination of cefcapene acid by LC–MS and their application to a pharmacokinetic study in healthy Chinese volunteers
por: Duan, Hong-Fei, et al.
Publicado: (2013)

Pharmacokinetics and Tolerability of Single and Multiple Intravenous Doses of Cefotetan Disodium in Healthy Chinese Volunteers
por: Liu, Jian, et al.
Publicado: (2020)

Safety and pharmacokinetics of dicloxacillin in healthy Chinese volunteers following single and multiple oral doses
por: Wu, Guolan, et al.
Publicado: (2015)

Safety of oral nemonoxacin: A systematic review of clinical trials and postmarketing surveillance
por: Yuan, Jinyi, et al.
Publicado: (2022)

Pharmacokinetics of Oral Taurine in Healthy Volunteers
por: Ghandforoush-Sattari, Mohammadreza, et al.
Publicado: (2010)

Pharmacokinetics of intranasal amiloride in healthy volunteers
por: Yellepeddi, Venkata K., et al.
Publicado: (2023)

Neuroprotective Effects of the Pannexin-1 Channel Inhibitor: Probenecid on Spinal Cord Injury in Rats
por: Qi, Qi, et al.
Publicado: (2022)

Study of GABA in Healthy Volunteers: Pharmacokinetics and Pharmacodynamics
por: Li, Junfeng, et al.
Publicado: (2015)

Effects of rifampin, cyclosporine A, and probenecid on the pharmacokinetic profile of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in healthy participants
por: Devineni, Damayanthi, et al.
Publicado: (2015)

Integrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers
por: Zhong, Yun-Xi, et al.
Publicado: (2016)

Pharmacokinetics and pharmacodynamics of levofloxacin injection in healthy Chinese volunteers and dosing regimen optimization
por: Cao, G, et al.
Publicado: (2013)

Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers
por: Gong, Chuting, et al.
Publicado: (2014)

Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers
por: Tang, Yong-Jun, et al.
Publicado: (2017)

Dermal effects and pharmacokinetic evaluation of the lidocaine/prilocaine cream in healthy Chinese volunteers
por: Li, Lingjun, et al.
Publicado: (2023)

Population Pharmacokinetic Analysis of Yimitasvir in Chinese Healthy Volunteers and Patients With Chronic Hepatitis C Virus Infection
por: Guan, Xiao-duo, et al.
Publicado: (2021)

Pharmacokinetics and Bioequivalence Study of Hydroxychloroquine Sulfate Tablets in Chinese Healthy Volunteers by LC–MS/MS
por: Fan, Hong-wei, et al.
Publicado: (2015)

Cimetidine enhancement of cyclophosphamide antitumour activity.
por: Dorr, R. T., et al.
Publicado: (1982)

Effect of ketoconazole on the pharmacokinetics of axitinib in healthy volunteers
por: Pithavala, Yazdi K., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_32tj1q1vh3hgpsf4cc9l5bt4ab