Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer

Local recurrence following definitive chemoradiation in cervical cancer ranges from 5-18%. Currently, there are limited options available for patients recurring in para-aortic or iliac lymph nodes. We present two cases of reirradiation for non-central recurrences with intensity-modulated radiotherap...

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Detalles Bibliográficos
Autores principales: Amini, Arya, Sumner, Whitney, Fisher, Christine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2015
Materias:
Radiation Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725673/
https://www.ncbi.nlm.nih.gov/pubmed/26824003
http://dx.doi.org/10.7759/cureus.399
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author Amini, Arya
Sumner, Whitney
Fisher, Christine M
author_facet Amini, Arya
Sumner, Whitney
Fisher, Christine M
author_sort Amini, Arya
collection PubMed
description Local recurrence following definitive chemoradiation in cervical cancer ranges from 5-18%. Currently, there are limited options available for patients recurring in para-aortic or iliac lymph nodes. We present two cases of reirradiation for non-central recurrences with intensity-modulated radiotherapy (IMRT). Both patients achieved a complete response with manageable short-term toxicities and no late adverse effects with a follow-up of over one year and three years after reirradiation. While further follow-up is needed, IMRT is a feasible and safe option in cervical cancer patients with recurrent in-field failures involving the lymph nodes.
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spelling pubmed-47256732016-01-28 Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer Amini, Arya Sumner, Whitney Fisher, Christine M Cureus Radiation Oncology Local recurrence following definitive chemoradiation in cervical cancer ranges from 5-18%. Currently, there are limited options available for patients recurring in para-aortic or iliac lymph nodes. We present two cases of reirradiation for non-central recurrences with intensity-modulated radiotherapy (IMRT). Both patients achieved a complete response with manageable short-term toxicities and no late adverse effects with a follow-up of over one year and three years after reirradiation. While further follow-up is needed, IMRT is a feasible and safe option in cervical cancer patients with recurrent in-field failures involving the lymph nodes. Cureus 2015-12-11 /pmc/articles/PMC4725673/ /pubmed/26824003 http://dx.doi.org/10.7759/cureus.399 Text en Copyright © 2015, Amini et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiation Oncology
Amini, Arya
Sumner, Whitney
Fisher, Christine M
Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title_full Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title_fullStr Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title_full_unstemmed Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title_short Durable Control and Overall Survival Benefit with Focal Reirradiation in Cervical Cancer
title_sort durable control and overall survival benefit with focal reirradiation in cervical cancer
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725673/
https://www.ncbi.nlm.nih.gov/pubmed/26824003
http://dx.doi.org/10.7759/cureus.399
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AT sumnerwhitney durablecontrolandoverallsurvivalbenefitwithfocalreirradiationincervicalcancer
AT fisherchristinem durablecontrolandoverallsurvivalbenefitwithfocalreirradiationincervicalcancer

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