Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy

Multiple myeloma is a disorder of malignant plasma cells, which is characterized by paraprotein production, lytic bone lesions, hypercalcemia, susceptibility to infections, and renal impairment. Here, we describe a patient with IgA myeloma with extensive nodal involvement who obtained significant be...

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Detalles Bibliográficos
Autores principales: Celotto, Kimberly, Neppalli, Vishala, Holstein, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2015
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725678/
https://www.ncbi.nlm.nih.gov/pubmed/26824011
http://dx.doi.org/10.7759/cureus.411
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author Celotto, Kimberly
Neppalli, Vishala
Holstein, Sarah
author_facet Celotto, Kimberly
Neppalli, Vishala
Holstein, Sarah
author_sort Celotto, Kimberly
collection PubMed
description Multiple myeloma is a disorder of malignant plasma cells, which is characterized by paraprotein production, lytic bone lesions, hypercalcemia, susceptibility to infections, and renal impairment. Here, we describe a patient with IgA myeloma with extensive nodal involvement who obtained significant benefit from high-dose methylprednisolone after failing aggressive induction chemotherapy and high-dose melphalan with autologous stem cell support.
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spelling pubmed-47256782016-01-28 Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy Celotto, Kimberly Neppalli, Vishala Holstein, Sarah Cureus Oncology Multiple myeloma is a disorder of malignant plasma cells, which is characterized by paraprotein production, lytic bone lesions, hypercalcemia, susceptibility to infections, and renal impairment. Here, we describe a patient with IgA myeloma with extensive nodal involvement who obtained significant benefit from high-dose methylprednisolone after failing aggressive induction chemotherapy and high-dose melphalan with autologous stem cell support. Cureus 2015-12-16 /pmc/articles/PMC4725678/ /pubmed/26824011 http://dx.doi.org/10.7759/cureus.411 Text en Copyright © 2015, Celotto et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Celotto, Kimberly
Neppalli, Vishala
Holstein, Sarah
Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title_full Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title_fullStr Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title_full_unstemmed Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title_short Remarkable Response to Methylprednisolone in a Multiple Myeloma Patient with Nodal Disease Refractory to High-Dose Chemotherapy
title_sort remarkable response to methylprednisolone in a multiple myeloma patient with nodal disease refractory to high-dose chemotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725678/
https://www.ncbi.nlm.nih.gov/pubmed/26824011
http://dx.doi.org/10.7759/cureus.411
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AT holsteinsarah remarkableresponsetomethylprednisoloneinamultiplemyelomapatientwithnodaldiseaserefractorytohighdosechemotherapy

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