Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity

A hallmark of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, is formation of inclusion bodies (IBs) from misfolded proteins in neuronal cells. TAR RNA/DNA-binding protein 43 kDa (TDP43) is an ALS-causative protein forming IBs in ALS patients. The relation between local...

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Detalles Bibliográficos
Autores principales: Kitamura, Akira, Nakayama, Yusaku, Shibasaki, Ai, Taki, Ayami, Yuno, Sachiko, Takeda, Kayo, Yahara, Masao, Tanabe, Naoki, Kinjo, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725827/
https://www.ncbi.nlm.nih.gov/pubmed/26757674
http://dx.doi.org/10.1038/srep19230

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