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Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration

Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this diff...

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Autores principales: Zhang, Xingdi, Zeng, Deliang, Li, Nan, Wen, Jin, Jiang, Xinquan, Liu, Changsheng, Li, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725866/
https://www.ncbi.nlm.nih.gov/pubmed/26763311
http://dx.doi.org/10.1038/srep19361
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author Zhang, Xingdi
Zeng, Deliang
Li, Nan
Wen, Jin
Jiang, Xinquan
Liu, Changsheng
Li, Yongsheng
author_facet Zhang, Xingdi
Zeng, Deliang
Li, Nan
Wen, Jin
Jiang, Xinquan
Liu, Changsheng
Li, Yongsheng
author_sort Zhang, Xingdi
collection PubMed
description Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this difficulty has greatly hindered its development and use. To solve this problem, a simple powder processing technique has been successfully developed to fabricate a novel type of MBG scaffold (MBGS). Furthermore, amino or carboxylic groups could be successfully grafted onto MBGSs (denoted as N-MBGS and C-MBGS, respectively) through a post-grafting process. It was revealed that both MBGS and the functionalized MBGSs could significantly promote the proliferation and osteogenic differentiation of bMSCs. Due to its positively charged surface, N-MBGS presented the highest in vitro osteogenic capability of the three samples. Moreover, in vivo testing results demonstrated that N-MBGS could promote higher levels of bone regeneration compared with MBGS and C-MBGS. In addition to its surface characteristics, it is believed that the decreased degradation rate of N-MBGS plays a vital role in promoting bone regeneration. These findings indicate that MBGSs are promising materials with potential practical applications in bone regeneration, which can be successfully fabricated by combining a powder processing technique and post-grafting process.
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spelling pubmed-47258662016-01-28 Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration Zhang, Xingdi Zeng, Deliang Li, Nan Wen, Jin Jiang, Xinquan Liu, Changsheng Li, Yongsheng Sci Rep Article Mesoporous bioactive glass (MBG), which possesses excellent bioactivity, biocompatibility and osteoconductivity, has played an important role in bone tissue regeneration. However, it is difficult to prepare MBG scaffolds with high compressive strength for applications in bone regeneration; this difficulty has greatly hindered its development and use. To solve this problem, a simple powder processing technique has been successfully developed to fabricate a novel type of MBG scaffold (MBGS). Furthermore, amino or carboxylic groups could be successfully grafted onto MBGSs (denoted as N-MBGS and C-MBGS, respectively) through a post-grafting process. It was revealed that both MBGS and the functionalized MBGSs could significantly promote the proliferation and osteogenic differentiation of bMSCs. Due to its positively charged surface, N-MBGS presented the highest in vitro osteogenic capability of the three samples. Moreover, in vivo testing results demonstrated that N-MBGS could promote higher levels of bone regeneration compared with MBGS and C-MBGS. In addition to its surface characteristics, it is believed that the decreased degradation rate of N-MBGS plays a vital role in promoting bone regeneration. These findings indicate that MBGSs are promising materials with potential practical applications in bone regeneration, which can be successfully fabricated by combining a powder processing technique and post-grafting process. Nature Publishing Group 2016-01-14 /pmc/articles/PMC4725866/ /pubmed/26763311 http://dx.doi.org/10.1038/srep19361 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Xingdi
Zeng, Deliang
Li, Nan
Wen, Jin
Jiang, Xinquan
Liu, Changsheng
Li, Yongsheng
Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title_full Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title_fullStr Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title_full_unstemmed Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title_short Functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
title_sort functionalized mesoporous bioactive glass scaffolds for enhanced bone tissue regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725866/
https://www.ncbi.nlm.nih.gov/pubmed/26763311
http://dx.doi.org/10.1038/srep19361
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