Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location

Liver repopulation by transplanted hepatocytes has not been achieved previously in a normal liver microenvironment. Here we report that adult rat hepatocytes transduced ex vivo with a lentivirus expressing a human YapERT2 fusion protein (hYapERT2) under control of the hepatocyte-specific transthyret...

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Detalles Bibliográficos
Autores principales: Yovchev, Mladen, Jaber, Fadi L., Lu, Zhonglei, Patel, Shachi, Locker, Joseph, Rogler, Leslie E., Murray, John W., Sudol, Marius, Dabeva, Mariana D., Zhu, Liang, Shafritz, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725878/
https://www.ncbi.nlm.nih.gov/pubmed/26763940
http://dx.doi.org/10.1038/srep19275

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