METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion

The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that METTTL13 protein is aberrant expression in variety of human cancers and METTL13 was involved in oncogenic pathways. However,...

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Autores principales: Zhang, Zhe, Zhang, Guojun, Kong, Chuize, Zhan, Bo, Dong, Xiao, Man, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725887/
https://www.ncbi.nlm.nih.gov/pubmed/26763933
http://dx.doi.org/10.1038/srep19261
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author Zhang, Zhe
Zhang, Guojun
Kong, Chuize
Zhan, Bo
Dong, Xiao
Man, Xiaojun
author_facet Zhang, Zhe
Zhang, Guojun
Kong, Chuize
Zhan, Bo
Dong, Xiao
Man, Xiaojun
author_sort Zhang, Zhe
collection PubMed
description The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that METTTL13 protein is aberrant expression in variety of human cancers and METTL13 was involved in oncogenic pathways. However, the role of METTL13 has been unexplored in bladder cancer to date. Here, expression of METTL13 was lower in bladder cancer tissue samples and cancer cell lines than in normal bladder tissue and cell lines. METTL13 was downregulated in the late stages of the disease and was maintained at low level throughout the tumor progression process based on tumor node metastasis (TNM) staging. Further research suggested that METTL13 negatively regulates cell proliferation in bladder cancer and reinstates G1/S checkpoint via the coordinated downregulation of CDK6, CDK4 and CCND1, decreased phosphorylation of Rb and subsequent delayed cell cycle progression. Moreover, METTL13-dependent inhibition of bladder cancer cell migration and invasion is mediated by downregulation of FAK (Focal adhesion kinase) phosphorylation, AKT (v-akt murine thymoma viral oncogene) phosphorylation, β-catenin expression and MMP-9 expression. These integrated efforts have identified METTL13 as a tumor suppressor and might provide promising approaches for bladder cancer treatment and prevention.
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spelling pubmed-47258872016-01-28 METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion Zhang, Zhe Zhang, Guojun Kong, Chuize Zhan, Bo Dong, Xiao Man, Xiaojun Sci Rep Article The incidence of bladder cancer has increased in the last few decades, thus novel markers for early diagnosis and more efficacious treatment are urgently needed. It found that METTTL13 protein is aberrant expression in variety of human cancers and METTL13 was involved in oncogenic pathways. However, the role of METTL13 has been unexplored in bladder cancer to date. Here, expression of METTL13 was lower in bladder cancer tissue samples and cancer cell lines than in normal bladder tissue and cell lines. METTL13 was downregulated in the late stages of the disease and was maintained at low level throughout the tumor progression process based on tumor node metastasis (TNM) staging. Further research suggested that METTL13 negatively regulates cell proliferation in bladder cancer and reinstates G1/S checkpoint via the coordinated downregulation of CDK6, CDK4 and CCND1, decreased phosphorylation of Rb and subsequent delayed cell cycle progression. Moreover, METTL13-dependent inhibition of bladder cancer cell migration and invasion is mediated by downregulation of FAK (Focal adhesion kinase) phosphorylation, AKT (v-akt murine thymoma viral oncogene) phosphorylation, β-catenin expression and MMP-9 expression. These integrated efforts have identified METTL13 as a tumor suppressor and might provide promising approaches for bladder cancer treatment and prevention. Nature Publishing Group 2016-01-14 /pmc/articles/PMC4725887/ /pubmed/26763933 http://dx.doi.org/10.1038/srep19261 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Zhe
Zhang, Guojun
Kong, Chuize
Zhan, Bo
Dong, Xiao
Man, Xiaojun
METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title_full METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title_fullStr METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title_full_unstemmed METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title_short METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
title_sort mettl13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725887/
https://www.ncbi.nlm.nih.gov/pubmed/26763933
http://dx.doi.org/10.1038/srep19261
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