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Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury

Adiponectin is an adipocyte-derived circulating protein with beneficial effects on injured livers. Adiponectin-deficient (adipo(−/−)) mice develop enhanced liver fibrosis, suggesting that adiponectin could be a therapeutic target for liver injury. In the present study, we investigated the protective...

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Autores principales: Wang, Huafeng, Zhang, Huan, Zhang, Zimu, Huang, Biao, Cheng, Xixi, Wang, Dan, la Gahu, Zha, Xue, Zhenyi, Da, Yurong, Li, Daiqing, Yao, Zhi, Gao, Fei, Xu, Aimin, Zhang, Rongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725969/
https://www.ncbi.nlm.nih.gov/pubmed/26777428
http://dx.doi.org/10.1038/srep19445
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author Wang, Huafeng
Zhang, Huan
Zhang, Zimu
Huang, Biao
Cheng, Xixi
Wang, Dan
la Gahu, Zha
Xue, Zhenyi
Da, Yurong
Li, Daiqing
Yao, Zhi
Gao, Fei
Xu, Aimin
Zhang, Rongxin
author_facet Wang, Huafeng
Zhang, Huan
Zhang, Zimu
Huang, Biao
Cheng, Xixi
Wang, Dan
la Gahu, Zha
Xue, Zhenyi
Da, Yurong
Li, Daiqing
Yao, Zhi
Gao, Fei
Xu, Aimin
Zhang, Rongxin
author_sort Wang, Huafeng
collection PubMed
description Adiponectin is an adipocyte-derived circulating protein with beneficial effects on injured livers. Adiponectin-deficient (adipo(−/−)) mice develop enhanced liver fibrosis, suggesting that adiponectin could be a therapeutic target for liver injury. In the present study, we investigated the protective role of ADP355, an adiponectin-based active short peptide, in thioacetamide (TAA)-induced acute injury and chronic liver fibrosis in mice. ADP355 remarkably reduced TAA-induced necroinflammation and liver fibrosis. ADP355 treatment increased liver glycogen, decreased serum alanine transaminase and alkaline phosphatase activity, and promoted body weight gain, hyper-proliferation and hypo-apoptosis. In addition, ADP355 administration suppressed the TAA-induced activation of hepatic stellate cells and macrophages in the liver. These were associated with the inactivation of TGF-β1/SMAD2 signaling and the promotion of AMPK and STAT3 signaling. Sensitivity of adipo(−/−) mice to chronic liver injury was decreased with ADP355. In conclusion, ADP355 could mimic adiponectin’s action and may be suitable for the preclinical or clinical therapy of chronic liver injury.
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spelling pubmed-47259692016-01-28 Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury Wang, Huafeng Zhang, Huan Zhang, Zimu Huang, Biao Cheng, Xixi Wang, Dan la Gahu, Zha Xue, Zhenyi Da, Yurong Li, Daiqing Yao, Zhi Gao, Fei Xu, Aimin Zhang, Rongxin Sci Rep Article Adiponectin is an adipocyte-derived circulating protein with beneficial effects on injured livers. Adiponectin-deficient (adipo(−/−)) mice develop enhanced liver fibrosis, suggesting that adiponectin could be a therapeutic target for liver injury. In the present study, we investigated the protective role of ADP355, an adiponectin-based active short peptide, in thioacetamide (TAA)-induced acute injury and chronic liver fibrosis in mice. ADP355 remarkably reduced TAA-induced necroinflammation and liver fibrosis. ADP355 treatment increased liver glycogen, decreased serum alanine transaminase and alkaline phosphatase activity, and promoted body weight gain, hyper-proliferation and hypo-apoptosis. In addition, ADP355 administration suppressed the TAA-induced activation of hepatic stellate cells and macrophages in the liver. These were associated with the inactivation of TGF-β1/SMAD2 signaling and the promotion of AMPK and STAT3 signaling. Sensitivity of adipo(−/−) mice to chronic liver injury was decreased with ADP355. In conclusion, ADP355 could mimic adiponectin’s action and may be suitable for the preclinical or clinical therapy of chronic liver injury. Nature Publishing Group 2016-01-18 /pmc/articles/PMC4725969/ /pubmed/26777428 http://dx.doi.org/10.1038/srep19445 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Wang, Huafeng
Zhang, Huan
Zhang, Zimu
Huang, Biao
Cheng, Xixi
Wang, Dan
la Gahu, Zha
Xue, Zhenyi
Da, Yurong
Li, Daiqing
Yao, Zhi
Gao, Fei
Xu, Aimin
Zhang, Rongxin
Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title_full Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title_fullStr Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title_full_unstemmed Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title_short Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
title_sort adiponectin-derived active peptide adp355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725969/
https://www.ncbi.nlm.nih.gov/pubmed/26777428
http://dx.doi.org/10.1038/srep19445
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