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Structure of the transmembrane domain of human nicastrin-a component of γ-secretase

Nicastrin is the largest component of γ-secretase that is an intramembrane protease important in the development of Alzheimer’s disease. Nicastrin contains a large extracellular domain, a single transmembrane (TM) domain, and a short C-terminus. Its TM domain is important for the γ-secretase complex...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Liew, Lynette Sin Yee, Li, Qingxin, Kang, CongBao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726005/ https://www.ncbi.nlm.nih.gov/pubmed/26776682 http://dx.doi.org/10.1038/srep19522

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