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Enhancement of human sodium iodide symporter gene therapy for breast cancer by HDAC inhibitor mediated transcriptional modulation

The aberrant expression of human sodium iodide symporter (NIS) in breast cancer (BC) has raised the possibility of using targeted radioiodide therapy. Here we investigate modulation of endogenous, functional NIS expression by histone deacetylase inhibitors (HDACi) in vitro and in vivo. Luciferase re...

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Detalles Bibliográficos
Autores principales:	Kelkar, Madhura G., Senthilkumar, Kalimuthu, Jadhav, Smita, Gupta, Sudeep, Ahn, Beyong-Cheol, De, Abhijit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726020/ https://www.ncbi.nlm.nih.gov/pubmed/26777440 http://dx.doi.org/10.1038/srep19341

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