Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activators

The recently emerged CRISPR/Cas9 technique has opened a new perspective on readily editing specific genes. When combined with transcription activators, it can precisely manipulate endogenous gene expression. Here, we enhanced the expression of endogenous Cdx2 and Gata6 genes by CRISPR-mediated activ...

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Detalles Bibliográficos
Autores principales: Wei, Shu, Zou, Qingjian, Lai, Sisi, Zhang, Quanjun, Li, Li, Yan, Quanmei, Zhou, Xiaoqing, Zhong, Huilin, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726097/
https://www.ncbi.nlm.nih.gov/pubmed/26782778
http://dx.doi.org/10.1038/srep19648

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