Divergent targets of glycolysis and oxidative phosphorylation result in additive effects of metformin and starvation in colon and breast cancer

Emerging evidence demonstrates that targeting energy metabolism is a promising strategy to fight cancer. Here we show that combining metformin and short-term starvation markedly impairs metabolism and growth of colon and breast cancer. The impairment in glycolytic flux caused by starvation is enhanc...

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Detalles Bibliográficos
Autores principales: Marini, Cecilia, Bianchi, Giovanna, Buschiazzo, Ambra, Ravera, Silvia, Martella, Roberto, Bottoni, Gianluca, Petretto, Andrea, Emionite, Laura, Monteverde, Elena, Capitanio, Selene, Inglese, Elvira, Fabbi, Marina, Bongioanni, Francesca, Garaboldi, Lucia, Bruzzi, Paolo, Orengo, Anna Maria, Raffaghello, Lizzia, Sambuceti, Gianmario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726140/
https://www.ncbi.nlm.nih.gov/pubmed/26794854
http://dx.doi.org/10.1038/srep19569

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