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Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins

Loss of Tsc1/Tsc2 results in excess cell growth that eventually forms hamartoma in multiple organs. Our study using a mouse model with Tsc1 conditionally knockout in mammary epithelium showed that Tsc1 deficiency impaired mammary development. Phosphorylated S6 was up-regulated in Tsc1(−/−) mammary e...

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Detalles Bibliográficos
Autores principales:	Qin, Zhenqi, Zheng, Hang, Zhou, Ling, Ou, Yanhua, Huang, Bin, Yan, Bo, Qin, Zhenshu, Yang, Cuilan, Su, Yongchun, Bai, Xiaochun, Guo, Jiasong, Lin, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726182/ https://www.ncbi.nlm.nih.gov/pubmed/26795955 http://dx.doi.org/10.1038/srep19587

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