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Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo

New therapies for glioblastoma (GBM) are needed, as five-year survival is <10%. The proteasome inhibitor marizomib (MRZ) has inhibitory and death-inducing properties unique from previous inhibitors such as bortezomib (BTZ), and has not been well examined in GBM. We evaluated the mechanism of deat...

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Detalles Bibliográficos
Autores principales:	Manton, Christa A., Johnson, Blake, Singh, Melissa, Bailey, Cavan P., Bouchier-Hayes, Lisa, Chandra, Joya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726202/ https://www.ncbi.nlm.nih.gov/pubmed/26804704 http://dx.doi.org/10.1038/srep18953

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