H2AX deficiency is associated with erythroid dysplasia and compromised haematopoietic stem cell function

Myelodysplastic syndromes (MDS) are clonal disorders of haematopoiesis characterised by dysplastic changes of major myeloid cell lines. However, the mechanisms underlying these dysplastic changes are poorly understood. Here, we used a genetically modified mouse model and human patient data to examin...

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Detalles Bibliográficos
Autores principales: Zhao, Baobing, Tan, Timothy L., Mei, Yang, Yang, Jing, Yu, Yiting, Verma, Amit, Liang, Ying, Gao, Juehua, Ji, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726203/
https://www.ncbi.nlm.nih.gov/pubmed/26791933
http://dx.doi.org/10.1038/srep19589

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