SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination

Cranial neural crest cells (CNCCs) delaminate from embryonic neural folds and migrate to pharyngeal arches, which give rise to most mid-facial structures. CNCC dysfunction plays a prominent role in the etiology of orofacial clefts, a frequent birth malformation. Heterozygous mutations in SPECC1L hav...

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Detalles Bibliográficos
Autores principales: Wilson, Nathan R., Olm-Shipman, Adam J., Acevedo, Diana S., Palaniyandi, Kanagaraj, Hall, Everett G., Kosa, Edina, Stumpff, Kelly M., Smith, Guerin J., Pitstick, Lenore, Liao, Eric C., Bjork, Bryan C., Czirok, Andras, Saadi, Irfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726231/
https://www.ncbi.nlm.nih.gov/pubmed/26787558
http://dx.doi.org/10.1038/srep17735

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