Combined ligand-observe (19)F and protein-observe (15)N,(1)H-HSQC NMR suggests phenylalanine as the key Δ-somatostatin residue recognized by human protein disulfide isomerase

Human protein disulphide isomerase (hPDI) is an endoplasmic reticulum (ER) based isomerase and folding chaperone. Molecular detail of ligand recognition and specificity of hPDI are poorly understood despite the importance of the hPDI for folding secreted proteins and its implication in diseases incl...

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Detalles Bibliográficos
Autores principales: Richards, Kirsty L., Rowe, Michelle L., Hudson, Paul B., Williamson, Richard A., Howard, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726260/
https://www.ncbi.nlm.nih.gov/pubmed/26786784
http://dx.doi.org/10.1038/srep19518

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