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Ligand-based virtual screening and inductive learning for identification of SIRT1 inhibitors in natural products

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase, and its dysregulation can lead to ageing, diabetes, and cancer. From 346 experimentally confirmed SIRT1 inhibitors, an inhibitor structure pattern was generated by inductive logic programming (ILP) with DMax Chemistry As...

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Detalles Bibliográficos
Autores principales:	Sun, Yunan, Zhou, Hui, Zhu, Hongmei, Leung, Siu-wai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726279/ https://www.ncbi.nlm.nih.gov/pubmed/26805727 http://dx.doi.org/10.1038/srep19312

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