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Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold

Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy contr...

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Detalles Bibliográficos
Autores principales: Moss, Penny, Knight, Emma, Wright, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726459/
https://www.ncbi.nlm.nih.gov/pubmed/26809009
http://dx.doi.org/10.1371/journal.pone.0147526
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author Moss, Penny
Knight, Emma
Wright, Anthony
author_facet Moss, Penny
Knight, Emma
Wright, Anthony
author_sort Moss, Penny
collection PubMed
description Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy control subjects. Twenty-three subjects with knee osteoarthritis and 23 healthy controls, matched for age, gender and body mass index, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure, cold and heat were tested at the knee, ipsilateral heel and ipsilateral elbow, in randomized order, using standardised methodology. Significant between-groups differences for pressure pain and cold pain thresholds were found with osteoarthritic subjects demonstrating significantly increased sensitivity to both pressure (p = .018) and cold (p = .003) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. No significant differences were found between groups for heat pain threshold, although correlations showed that subjects with greater sensitivity to pressure pain were also likely to be more sensitive to both cold pain and heat pain. This study found widespread elevated pain thresholds in subjects with painful knee osteoarthritis, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients.
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spelling pubmed-47264592016-02-03 Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold Moss, Penny Knight, Emma Wright, Anthony PLoS One Research Article Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy control subjects. Twenty-three subjects with knee osteoarthritis and 23 healthy controls, matched for age, gender and body mass index, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure, cold and heat were tested at the knee, ipsilateral heel and ipsilateral elbow, in randomized order, using standardised methodology. Significant between-groups differences for pressure pain and cold pain thresholds were found with osteoarthritic subjects demonstrating significantly increased sensitivity to both pressure (p = .018) and cold (p = .003) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. No significant differences were found between groups for heat pain threshold, although correlations showed that subjects with greater sensitivity to pressure pain were also likely to be more sensitive to both cold pain and heat pain. This study found widespread elevated pain thresholds in subjects with painful knee osteoarthritis, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients. Public Library of Science 2016-01-25 /pmc/articles/PMC4726459/ /pubmed/26809009 http://dx.doi.org/10.1371/journal.pone.0147526 Text en © 2016 Moss et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Moss, Penny
Knight, Emma
Wright, Anthony
Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title_full Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title_fullStr Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title_full_unstemmed Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title_short Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
title_sort subjects with knee osteoarthritis exhibit widespread hyperalgesia to pressure and cold
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726459/
https://www.ncbi.nlm.nih.gov/pubmed/26809009
http://dx.doi.org/10.1371/journal.pone.0147526
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