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Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold
Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy contr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726459/ https://www.ncbi.nlm.nih.gov/pubmed/26809009 http://dx.doi.org/10.1371/journal.pone.0147526 |
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author | Moss, Penny Knight, Emma Wright, Anthony |
author_facet | Moss, Penny Knight, Emma Wright, Anthony |
author_sort | Moss, Penny |
collection | PubMed |
description | Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy control subjects. Twenty-three subjects with knee osteoarthritis and 23 healthy controls, matched for age, gender and body mass index, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure, cold and heat were tested at the knee, ipsilateral heel and ipsilateral elbow, in randomized order, using standardised methodology. Significant between-groups differences for pressure pain and cold pain thresholds were found with osteoarthritic subjects demonstrating significantly increased sensitivity to both pressure (p = .018) and cold (p = .003) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. No significant differences were found between groups for heat pain threshold, although correlations showed that subjects with greater sensitivity to pressure pain were also likely to be more sensitive to both cold pain and heat pain. This study found widespread elevated pain thresholds in subjects with painful knee osteoarthritis, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients. |
format | Online Article Text |
id | pubmed-4726459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47264592016-02-03 Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold Moss, Penny Knight, Emma Wright, Anthony PLoS One Research Article Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of local and widespread mechanical and thermal hyperalgesia in individuals with knee osteoarthritis, compared to healthy control subjects. Twenty-three subjects with knee osteoarthritis and 23 healthy controls, matched for age, gender and body mass index, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure, cold and heat were tested at the knee, ipsilateral heel and ipsilateral elbow, in randomized order, using standardised methodology. Significant between-groups differences for pressure pain and cold pain thresholds were found with osteoarthritic subjects demonstrating significantly increased sensitivity to both pressure (p = .018) and cold (p = .003) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. No significant differences were found between groups for heat pain threshold, although correlations showed that subjects with greater sensitivity to pressure pain were also likely to be more sensitive to both cold pain and heat pain. This study found widespread elevated pain thresholds in subjects with painful knee osteoarthritis, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients. Public Library of Science 2016-01-25 /pmc/articles/PMC4726459/ /pubmed/26809009 http://dx.doi.org/10.1371/journal.pone.0147526 Text en © 2016 Moss et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Moss, Penny Knight, Emma Wright, Anthony Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title | Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title_full | Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title_fullStr | Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title_full_unstemmed | Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title_short | Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold |
title_sort | subjects with knee osteoarthritis exhibit widespread hyperalgesia to pressure and cold |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726459/ https://www.ncbi.nlm.nih.gov/pubmed/26809009 http://dx.doi.org/10.1371/journal.pone.0147526 |
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