Cargando…

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Ubiquitin-specific protease 19 (USP19) is one of the deubiquitinating enzymes (DUBs) involved in regulating the ubiquitination status of substrate proteins. There are two major isoforms of USP19 with distinct C-termini; the USP19_a isoform has a transmembrane domain for anchoring to the endoplasmic...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Wen-Tian, Zheng, Xue-Ming, Zhang, Yu-Hang, Gao, Yong-Guang, Song, Ai-Xin, van der Goot, Françoise Gisou, Hu, Hong-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726498/ https://www.ncbi.nlm.nih.gov/pubmed/26808260 http://dx.doi.org/10.1371/journal.pone.0147515

Ejemplares similares

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1
por: Ni, Chun-Lun, et al.
Publicado: (2016)

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19
por: He, Wen-Tian, et al.
Publicado: (2017)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1
por: Parfitt, David A., et al.
Publicado: (2009)

Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation
por: Johnson, Sean L, et al.
Publicado: (2020)

OR26-3 USP19 Deubiquitinating Enzyme Functions as a Novel Co-Chaperone of Hsp90 to Regulate Glucocorticoid Receptor Levels
por: Bedard, Nathalie, et al.
Publicado: (2022)

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
por: Macdonald, Douglas, et al.
Publicado: (2014)

Hsp110 Chaperones Control Client Fate Determination in the Hsp70–Hsp90 Chaperone System
por: Mandal, Atin K., et al.
Publicado: (2010)

A Structural Study of the Cytoplasmic Chaperone Effect of 14-3-3 Proteins on Ataxin-1
por: Leysen, Seppe, et al.
Publicado: (2021)

Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
por: Kotowska-Zimmer, Anna, et al.
Publicado: (2019)

Polyglutamine Expansion Accelerates the Dynamics of Ataxin-1 and Does Not Result in Aggregate Formation
por: Krol, Hilde A., et al.
Publicado: (2008)

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
por: Elden, Andrew C., et al.
Publicado: (2010)

Autophagy mediates SUMO-induced degradation of a polyglutamine protein ataxin-3
por: Hwang, Soo Pyung, et al.
Publicado: (2017)

Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
por: McIntosh, Craig S., et al.
Publicado: (2019)

The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases
por: Lackie, Rachel E., et al.
Publicado: (2017)

Polyglutamine-Rich Suppressors of Huntingtin Toxicity Act Upstream of Hsp70 and Sti1 in Spatial Quality Control of Amyloid-Like Proteins
por: Wolfe, Katie J., et al.
Publicado: (2014)

The chaperone system in cancer therapies: Hsp90
por: Basset, Charbel A., et al.
Publicado: (2023)

Alterations of the Hsp70/Hsp90 chaperone and the HOP/CHIP co-chaperone system in cancer
por: Ruckova, Eva, et al.
Publicado: (2012)

PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins
por: Janer, Alexandre, et al.
Publicado: (2006)

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila
por: Voßfeldt, Hannes, et al.
Publicado: (2012)

The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90
por: Alberti, Giusi, et al.
Publicado: (2022)

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
por: Reidy, Michael, et al.
Publicado: (2014)

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies
por: Shelton, Lindsey B., et al.
Publicado: (2017)

Review: The HSP90 molecular chaperone—an enigmatic ATPase
por: Pearl, Laurence H.
Publicado: (2016)

Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases
por: Bohush, Anastasiia, et al.
Publicado: (2019)

Hsp90 and Associated Co-Chaperones of the Malaria Parasite
por: Dutta, Tanima, et al.
Publicado: (2022)

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery
por: Li, Ting, et al.
Publicado: (2018)

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences
por: Lakhani, Vinal V., et al.
Publicado: (2010)

Deletion of the Huntingtin Polyglutamine Stretch Enhances Neuronal Autophagy and Longevity in Mice
por: Zheng, Shuqiu, et al.
Publicado: (2010)

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
por: Daldin, Manuel, et al.
Publicado: (2017)

Conformational switch of polyglutamine-expanded huntingtin into benign aggregates leads to neuroprotective effect
por: Sun, Chia-Sui, et al.
Publicado: (2015)

Glucose intake hampers PKA-regulated HSP90 chaperone activity
por: Chen, Yu-Chen, et al.
Publicado: (2018)

Development of mAb-based polyglutamine-dependent and polyglutamine length-independent huntingtin quantification assays with cross-site validation
por: Fischer, David F., et al.
Publicado: (2022)

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation
por: Natalello, Antonino, et al.
Publicado: (2011)

p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine
por: Zhou, Liang, et al.
Publicado: (2014)

The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
por: Invernizzi, Gaetano, et al.
Publicado: (2012)

A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3
por: Scarff, Charlotte A., et al.
Publicado: (2013)

Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3
por: Koike, Yuka, et al.
Publicado: (2021)

Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
por: Kohiyama, Mayumi F., et al.
Publicado: (2016)

Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch
por: Kuiper, E. F. E., et al.
Publicado: (2017)

Distinct Roles of Molecular Chaperones HSP90α and HSP90β in the Biogenesis of KCNQ4 Channels
por: Gao, Yanhong, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_mk5hhii595o5vm155u36c0nr9f