Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association studies (GWAS) across genes and pathways is a strategy to improve statistical power and gain biological insight. Here, we present Pascal (Pathway scoring algorithm), a powerful tool for computing gene and pathway...

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Detalles Bibliográficos
Autores principales: Lamparter, David, Marbach, Daniel, Rueedi, Rico, Kutalik, Zoltán, Bergmann, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726509/
https://www.ncbi.nlm.nih.gov/pubmed/26808494
http://dx.doi.org/10.1371/journal.pcbi.1004714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726509/
https://www.ncbi.nlm.nih.gov/pubmed/26808494
http://dx.doi.org/10.1371/journal.pcbi.1004714

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