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Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics
Integrating single nucleotide polymorphism (SNP) p-values from genome-wide association studies (GWAS) across genes and pathways is a strategy to improve statistical power and gain biological insight. Here, we present Pascal (Pathway scoring algorithm), a powerful tool for computing gene and pathway...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726509/ https://www.ncbi.nlm.nih.gov/pubmed/26808494 http://dx.doi.org/10.1371/journal.pcbi.1004714 |