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A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder

BACKGROUND: Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morpho...

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Autores principales: Jin, Xinhu, Zhong, Mingtian, Yao, Shuqiao, Cao, Xiyu, Tan, Changlian, Gan, Jun, Zhu, Xiongzhao, Yi, Jinyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726531/
https://www.ncbi.nlm.nih.gov/pubmed/26808504
http://dx.doi.org/10.1371/journal.pone.0147938
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author Jin, Xinhu
Zhong, Mingtian
Yao, Shuqiao
Cao, Xiyu
Tan, Changlian
Gan, Jun
Zhu, Xiongzhao
Yi, Jinyao
author_facet Jin, Xinhu
Zhong, Mingtian
Yao, Shuqiao
Cao, Xiyu
Tan, Changlian
Gan, Jun
Zhu, Xiongzhao
Yi, Jinyao
author_sort Jin, Xinhu
collection PubMed
description BACKGROUND: Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morphometry (VBM) have focused on attachment and childhood trauma in BPD. This preliminary study was performed to investigate structural brain changes and their relationships to attachment and childhood trauma in a homogenous sample of young adults with BPD. METHOD: We examined 34 young adults with BPD and 34 healthy controls (HCs) to assess regionally specific differences in gray matter volume (GMV) and gray matter concentration (GMC). Multiple regressions between brain volumes measured by VBM and attachment style questionnaire (ASQ) and childhood trauma questionnaire (CTQ) scores were performed. RESULTS: Compared with HCs, subjects with BPD showed significant bilateral increases in GMV in the middle cingulate cortex (MCC)/posterior cingulate cortex (PCC)/precuneus. GMC did not differ significantly between groups. In multiple regression models, ASQ insecure attachment scores were correlated negatively with GMV in the precuneus/MCC and middle occipital gyrus in HCs, HCs with more severe insecure attachment showed smaller volumes in precuneus/MCC and middle occipital gyrus, whereas no negative correlations between insecure attachment and GMV in any region were found in BPD group. In addition, CTQ total scores were not correlated with GMV in any region in the two groups respectively. CONCLUSIONS: Our findings fit with those of previous reports of larger precuneus GMV in patients with BPD, and suggest that GMV in the precuneus/MCC and middle occipital gyrus is associated inversely with insecure attachment style in HCs. Our finding of increased GMV in the MCC and PCC in patients with BPD compared with HCs has not been reported in previous VBM studies.
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spelling pubmed-47265312016-02-03 A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder Jin, Xinhu Zhong, Mingtian Yao, Shuqiao Cao, Xiyu Tan, Changlian Gan, Jun Zhu, Xiongzhao Yi, Jinyao PLoS One Research Article BACKGROUND: Increasing evidence has documented subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). However, results of magnetic resonance imaging volumetry in patients with BPD are inconsistent. In addition, few researchers using voxel-based morphometry (VBM) have focused on attachment and childhood trauma in BPD. This preliminary study was performed to investigate structural brain changes and their relationships to attachment and childhood trauma in a homogenous sample of young adults with BPD. METHOD: We examined 34 young adults with BPD and 34 healthy controls (HCs) to assess regionally specific differences in gray matter volume (GMV) and gray matter concentration (GMC). Multiple regressions between brain volumes measured by VBM and attachment style questionnaire (ASQ) and childhood trauma questionnaire (CTQ) scores were performed. RESULTS: Compared with HCs, subjects with BPD showed significant bilateral increases in GMV in the middle cingulate cortex (MCC)/posterior cingulate cortex (PCC)/precuneus. GMC did not differ significantly between groups. In multiple regression models, ASQ insecure attachment scores were correlated negatively with GMV in the precuneus/MCC and middle occipital gyrus in HCs, HCs with more severe insecure attachment showed smaller volumes in precuneus/MCC and middle occipital gyrus, whereas no negative correlations between insecure attachment and GMV in any region were found in BPD group. In addition, CTQ total scores were not correlated with GMV in any region in the two groups respectively. CONCLUSIONS: Our findings fit with those of previous reports of larger precuneus GMV in patients with BPD, and suggest that GMV in the precuneus/MCC and middle occipital gyrus is associated inversely with insecure attachment style in HCs. Our finding of increased GMV in the MCC and PCC in patients with BPD compared with HCs has not been reported in previous VBM studies. Public Library of Science 2016-01-25 /pmc/articles/PMC4726531/ /pubmed/26808504 http://dx.doi.org/10.1371/journal.pone.0147938 Text en © 2016 Jin et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Jin, Xinhu
Zhong, Mingtian
Yao, Shuqiao
Cao, Xiyu
Tan, Changlian
Gan, Jun
Zhu, Xiongzhao
Yi, Jinyao
A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title_full A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title_fullStr A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title_full_unstemmed A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title_short A Voxel-Based Morphometric MRI Study in Young Adults with Borderline Personality Disorder
title_sort voxel-based morphometric mri study in young adults with borderline personality disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726531/
https://www.ncbi.nlm.nih.gov/pubmed/26808504
http://dx.doi.org/10.1371/journal.pone.0147938
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