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Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro

Hemoglobin E (HbE) is one of the most common hemoglobin variants caused by a mutation in the β-globin gene, and found at high frequencies in various Southeast Asian groups. We surveyed HbE prevalence among 8 ethnic groups residing in 5 villages selected for their high period malaria endemicity, and...

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Autores principales: Lithanatudom, Pathrapol, Wipasa, Jiraprapa, Inti, Pitsinee, Chawansuntati, Kriangkrai, Svasti, Saovaros, Fucharoen, Suthat, Kangwanpong, Daoroong, Kampuansai, Jatupol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726726/
https://www.ncbi.nlm.nih.gov/pubmed/26808200
http://dx.doi.org/10.1371/journal.pone.0148079
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author Lithanatudom, Pathrapol
Wipasa, Jiraprapa
Inti, Pitsinee
Chawansuntati, Kriangkrai
Svasti, Saovaros
Fucharoen, Suthat
Kangwanpong, Daoroong
Kampuansai, Jatupol
author_facet Lithanatudom, Pathrapol
Wipasa, Jiraprapa
Inti, Pitsinee
Chawansuntati, Kriangkrai
Svasti, Saovaros
Fucharoen, Suthat
Kangwanpong, Daoroong
Kampuansai, Jatupol
author_sort Lithanatudom, Pathrapol
collection PubMed
description Hemoglobin E (HbE) is one of the most common hemoglobin variants caused by a mutation in the β-globin gene, and found at high frequencies in various Southeast Asian groups. We surveyed HbE prevalence among 8 ethnic groups residing in 5 villages selected for their high period malaria endemicity, and 5 for low endemicity in northern Thailand, in order to uncover factors which may affect genetic persistence of HbE in these groups. We found the overall HbE prevalence 6.7%, with differing frequencies from 0% in the Pwo Karen, the Lawa, and the Skaw Karen to 24% in the Mon. All HbE genes were heterozygous (AE). Differences in HbE prevalence among the studied ethnic groups indirectly documents that ancestries and evolutionary forces, such as drift and admixture, are the important factors in the persistence of HbE distribution in northern Thailand. Furthermore, the presence of HbE in groups of northern Thailand had no effect on the in vitro infectivity and proliferation of Plasmodium falciparum, nor the production of hemozoin, a heme crystal produced by malaria parasites, when compared to normal red-blood-cell controls. Our data may contribute to a better understanding on the persistence of HbE among ethnic groups and its association with malaria.
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spelling pubmed-47267262016-02-03 Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro Lithanatudom, Pathrapol Wipasa, Jiraprapa Inti, Pitsinee Chawansuntati, Kriangkrai Svasti, Saovaros Fucharoen, Suthat Kangwanpong, Daoroong Kampuansai, Jatupol PLoS One Research Article Hemoglobin E (HbE) is one of the most common hemoglobin variants caused by a mutation in the β-globin gene, and found at high frequencies in various Southeast Asian groups. We surveyed HbE prevalence among 8 ethnic groups residing in 5 villages selected for their high period malaria endemicity, and 5 for low endemicity in northern Thailand, in order to uncover factors which may affect genetic persistence of HbE in these groups. We found the overall HbE prevalence 6.7%, with differing frequencies from 0% in the Pwo Karen, the Lawa, and the Skaw Karen to 24% in the Mon. All HbE genes were heterozygous (AE). Differences in HbE prevalence among the studied ethnic groups indirectly documents that ancestries and evolutionary forces, such as drift and admixture, are the important factors in the persistence of HbE distribution in northern Thailand. Furthermore, the presence of HbE in groups of northern Thailand had no effect on the in vitro infectivity and proliferation of Plasmodium falciparum, nor the production of hemozoin, a heme crystal produced by malaria parasites, when compared to normal red-blood-cell controls. Our data may contribute to a better understanding on the persistence of HbE among ethnic groups and its association with malaria. Public Library of Science 2016-01-25 /pmc/articles/PMC4726726/ /pubmed/26808200 http://dx.doi.org/10.1371/journal.pone.0148079 Text en © 2016 Lithanatudom et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lithanatudom, Pathrapol
Wipasa, Jiraprapa
Inti, Pitsinee
Chawansuntati, Kriangkrai
Svasti, Saovaros
Fucharoen, Suthat
Kangwanpong, Daoroong
Kampuansai, Jatupol
Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title_full Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title_fullStr Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title_full_unstemmed Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title_short Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro
title_sort hemoglobin e prevalence among ethnic groups residing in malaria-endemic areas of northern thailand and its lack of association with plasmodium falciparum invasion in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726726/
https://www.ncbi.nlm.nih.gov/pubmed/26808200
http://dx.doi.org/10.1371/journal.pone.0148079
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