Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species

Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylos...

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Autores principales: Bador, J., Neuwirth, C., Liszczynski, P., Mézier, M.-C., Chrétiennot, M., Grenot, E., Chapuis, A., de Curraize, C., Amoureux, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
New Resistant Microbes in Humans
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726742/
https://www.ncbi.nlm.nih.gov/pubmed/26904200
http://dx.doi.org/10.1016/j.nmni.2015.11.013
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author Bador, J.
Neuwirth, C.
Liszczynski, P.
Mézier, M.-C.
Chrétiennot, M.
Grenot, E.
Chapuis, A.
de Curraize, C.
Amoureux, L.
author_facet Bador, J.
Neuwirth, C.
Liszczynski, P.
Mézier, M.-C.
Chrétiennot, M.
Grenot, E.
Chapuis, A.
de Curraize, C.
Amoureux, L.
author_sort Bador, J.
collection PubMed
description Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis.
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spelling pubmed-47267422016-02-22 Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species Bador, J. Neuwirth, C. Liszczynski, P. Mézier, M.-C. Chrétiennot, M. Grenot, E. Chapuis, A. de Curraize, C. Amoureux, L. New Microbes New Infect New Resistant Microbes in Humans Achromobacter spp. are emerging respiratory pathogens in cystic fibrosis patients. Since 2013 the genus Achromobacter includes 15 species for which innate antibiotic resistance is unknown. Previously the AxyXY-OprZ efflux system has been described to confer aminoglycoside (AG) resistance in A. xylosoxidans. Nevertheless, some Achromobacter spp. strains are susceptible to AG. This study including 49 Achromobacter isolates reveals that AG resistance is correlated with different Achromobacter spp. It is noteworthy that the axyXY-oprZ operon is detected only in AG-resistant species, including the most frequently encountered in cystic fibrosis patients: A. xylosoxidans, A. ruhlandii, A. dolens and A. insuavis. Elsevier 2015-12-12 /pmc/articles/PMC4726742/ /pubmed/26904200 http://dx.doi.org/10.1016/j.nmni.2015.11.013 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle New Resistant Microbes in Humans
Bador, J.
Neuwirth, C.
Liszczynski, P.
Mézier, M.-C.
Chrétiennot, M.
Grenot, E.
Chapuis, A.
de Curraize, C.
Amoureux, L.
Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title_full Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title_fullStr Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title_full_unstemmed Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title_short Distribution of innate efflux-mediated aminoglycoside resistance among different Achromobacter species
title_sort distribution of innate efflux-mediated aminoglycoside resistance among different achromobacter species
topic New Resistant Microbes in Humans
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726742/
https://www.ncbi.nlm.nih.gov/pubmed/26904200
http://dx.doi.org/10.1016/j.nmni.2015.11.013
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