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Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis

Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of t...

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Autores principales: WANG, JIFENG, JI, WENLI, XU, ZHENGQIN, PAN, TAO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726858/
https://www.ncbi.nlm.nih.gov/pubmed/26889232
http://dx.doi.org/10.3892/etm.2015.2863
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author WANG, JIFENG
JI, WENLI
XU, ZHENGQIN
PAN, TAO
author_facet WANG, JIFENG
JI, WENLI
XU, ZHENGQIN
PAN, TAO
author_sort WANG, JIFENG
collection PubMed
description Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT-proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT-proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT-proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis.
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spelling pubmed-47268582016-02-17 Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis WANG, JIFENG JI, WENLI XU, ZHENGQIN PAN, TAO Exp Ther Med Articles Sepsis is a systemic inflammatory response of the body to an antigen and can become a life-threatening condition by triggering a cascade of changes leading to multiple organ failure such as heart failure. The aim of the present study was to examine the changes of the plasma levels of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in patients with sepsis and to analyze their prognostic significance. A total of 38 hospitalized patients with sepsis were included in the present study. The patients were divided into the survival and death groups, based on their prognosis. The plasma levels of NT-proBNP and cTnT for the two groups were measured for all the patients on the 1st, 3rd and 7th day of admission. The plasma levels of NT-proBNP and cTnT between the two groups were compared and their association with prognosis were analyzed. The plasma levels of NT-proBNP and cTnT in the death group were significantly higher than those in the survival group (P<0.05). Additionally, a positive assocciation of the plasma levels of NT-proBNP and cTnT was identified (P<0.05). In conclusion, the plasma levels of NT-proBNP and cTnT may be used as routine clinical biomarkers to assess the prognosis of patients with sepsis. D.A. Spandidos 2016-01 2015-11-12 /pmc/articles/PMC4726858/ /pubmed/26889232 http://dx.doi.org/10.3892/etm.2015.2863 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
WANG, JIFENG
JI, WENLI
XU, ZHENGQIN
PAN, TAO
Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title_full Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title_fullStr Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title_full_unstemmed Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title_short Clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin T in patients with sepsis
title_sort clinical significance of plasma levels of brain natriuretic peptide and cardiac troponin t in patients with sepsis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726858/
https://www.ncbi.nlm.nih.gov/pubmed/26889232
http://dx.doi.org/10.3892/etm.2015.2863
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