Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran

BACKGROUND: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to...

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Autores principales: Golabgir Khademi, Khadijeh, Foroughmand, Ali Mohammad, Galehdari, Hamid, Yazdankhah, Saied, Pourmahdi Borujeni, Mahdi, Shahbazi, Zahra, Dinarvand, Parvaneh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726893/
https://www.ncbi.nlm.nih.gov/pubmed/26597055
http://dx.doi.org/10.7508/ibj.2016.02.008
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author Golabgir Khademi, Khadijeh
Foroughmand, Ali Mohammad
Galehdari, Hamid
Yazdankhah, Saied
Pourmahdi Borujeni, Mahdi
Shahbazi, Zahra
Dinarvand, Parvaneh
author_facet Golabgir Khademi, Khadijeh
Foroughmand, Ali Mohammad
Galehdari, Hamid
Yazdankhah, Saied
Pourmahdi Borujeni, Mahdi
Shahbazi, Zahra
Dinarvand, Parvaneh
author_sort Golabgir Khademi, Khadijeh
collection PubMed
description BACKGROUND: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. METHODS: Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism. RESULTS: Chi-square test showed no association between rs1333040 SNP and CAD (X(2): 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X(2): 0.27, df: 2, P=0.88). CONCLUSION: No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran.
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spelling pubmed-47268932016-04-01 Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran Golabgir Khademi, Khadijeh Foroughmand, Ali Mohammad Galehdari, Hamid Yazdankhah, Saied Pourmahdi Borujeni, Mahdi Shahbazi, Zahra Dinarvand, Parvaneh Iran Biomed J Short Communication BACKGROUND: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. METHODS: Blood samples were collected from 200 CAD patients and 110 healthy individuals with no CAD. The association of two SNPs with CAD was evaluated by PCR and restriction fragment length polymorphism. RESULTS: Chi-square test showed no association between rs1333040 SNP and CAD (X(2): 4.66, df: 2, P=0.09). Also, there was no association between rs1004638 SNP and CAD (X(2): 0.27, df: 2, P=0.88). CONCLUSION: No association was observed between rs1333040 and rs1004638 SNPs in the 9P21 region and CAD in Southwest of Iran. Pasteur Institute of Iran 2016-04 /pmc/articles/PMC4726893/ /pubmed/26597055 http://dx.doi.org/10.7508/ibj.2016.02.008 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Golabgir Khademi, Khadijeh
Foroughmand, Ali Mohammad
Galehdari, Hamid
Yazdankhah, Saied
Pourmahdi Borujeni, Mahdi
Shahbazi, Zahra
Dinarvand, Parvaneh
Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title_full Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title_fullStr Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title_full_unstemmed Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title_short Association Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
title_sort association study of rs1333040 and rs1004638 polymorphisms in the 9p21 locus with coronary artery disease in southwest of iran
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726893/
https://www.ncbi.nlm.nih.gov/pubmed/26597055
http://dx.doi.org/10.7508/ibj.2016.02.008
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