Cargando…

A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression

Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-...

Descripción completa

Detalles Bibliográficos
Autores principales: de Paula, Jonas J., Bicalho, Maria A., Ávila, Rafaela T., Cintra, Marco T. G., Diniz, Breno S., Romano-Silva, Marco A., Malloy-Diniz, Leandro F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727063/
https://www.ncbi.nlm.nih.gov/pubmed/26858666
http://dx.doi.org/10.3389/fpsyg.2015.02061
_version_ 1782411919436546048
author de Paula, Jonas J.
Bicalho, Maria A.
Ávila, Rafaela T.
Cintra, Marco T. G.
Diniz, Breno S.
Romano-Silva, Marco A.
Malloy-Diniz, Leandro F.
author_facet de Paula, Jonas J.
Bicalho, Maria A.
Ávila, Rafaela T.
Cintra, Marco T. G.
Diniz, Breno S.
Romano-Silva, Marco A.
Malloy-Diniz, Leandro F.
author_sort de Paula, Jonas J.
collection PubMed
description Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum.
format Online
Article
Text
id pubmed-4727063
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-47270632016-02-08 A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression de Paula, Jonas J. Bicalho, Maria A. Ávila, Rafaela T. Cintra, Marco T. G. Diniz, Breno S. Romano-Silva, Marco A. Malloy-Diniz, Leandro F. Front Psychol Psychology Depressive symptoms are associated with cognitive-functional impairment in normal aging older adults (NA). However, less is known about this effect on people with mild Cognitive Impairment (MCI) and mild Alzheimer's disease dementia (AD). We investigated this relationship along with the NA-MCI-AD continuum by reanalyzing a previously published dataset. Participants (N = 274) underwent comprehensive neuropsychological assessment including measures of Executive Function, Language/Semantic Memory, Episodic Memory, Visuospatial Abilities, Activities of Daily Living (ADL), and the Geriatric Depression Scale. MANOVA, logistic regression and chi-square tests were performed to assess the association between depression and cognitive-functional performance in each group. In the NA group, depressed participants had a lower performance compared to non-depressed participants in all cognitive and functional domains. However, the same pattern was not observed in the MCI group or in AD. The results suggest a progressive loss of association between depression and worse cognitive-functional performance along the NA-MCI-AD continuum. Frontiers Media S.A. 2016-01-26 /pmc/articles/PMC4727063/ /pubmed/26858666 http://dx.doi.org/10.3389/fpsyg.2015.02061 Text en Copyright © 2016 de Paula, Bicalho, Ávila, Cintra, Diniz, Romano-Silva and Malloy-Diniz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
de Paula, Jonas J.
Bicalho, Maria A.
Ávila, Rafaela T.
Cintra, Marco T. G.
Diniz, Breno S.
Romano-Silva, Marco A.
Malloy-Diniz, Leandro F.
A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title_full A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title_fullStr A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title_full_unstemmed A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title_short A Reanalysis of Cognitive-Functional Performance in Older Adults: Investigating the Interaction Between Normal Aging, Mild Cognitive Impairment, Mild Alzheimer's Disease Dementia, and Depression
title_sort reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild alzheimer's disease dementia, and depression
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727063/
https://www.ncbi.nlm.nih.gov/pubmed/26858666
http://dx.doi.org/10.3389/fpsyg.2015.02061
work_keys_str_mv AT depaulajonasj areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT bicalhomariaa areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT avilarafaelat areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT cintramarcotg areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT dinizbrenos areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT romanosilvamarcoa areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT malloydinizleandrof areanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT depaulajonasj reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT bicalhomariaa reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT avilarafaelat reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT cintramarcotg reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT dinizbrenos reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT romanosilvamarcoa reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression
AT malloydinizleandrof reanalysisofcognitivefunctionalperformanceinolderadultsinvestigatingtheinteractionbetweennormalagingmildcognitiveimpairmentmildalzheimersdiseasedementiaanddepression