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ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

BACKGROUND: A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuroplasticity. Despite the beneficial effect of ADAMTS-4 on neurorepair after spinal...

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Detalles Bibliográficos
Autores principales:	Lemarchant, Sighild, Pomeshchik, Yuriy, Kidin, Iurii, Kärkkäinen, Virve, Valonen, Piia, Lehtonen, Sarka, Goldsteins, Gundars, Malm, Tarja, Kanninen, Katja, Koistinaho, Jari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727317/ https://www.ncbi.nlm.nih.gov/pubmed/26809777 http://dx.doi.org/10.1186/s13024-016-0078-3

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