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Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder

BACKGROUND: Posttraumatic stress disorder (PTSD) is a disabling and prevalent psychiatric disorder with limited effective treatment options. In addition to the clinical features of the disease, pathologic changes in the electroencephalogram (EEG), including decreased alpha power, have been reported....

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Autores principales: Taghva, Alexander, Silvetz, Robert, Ring, Alex, Kim, Keun-young A., Murphy, Kevin T., Liu, Charles Y., Jin, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727473/
https://www.ncbi.nlm.nih.gov/pubmed/26839865
http://dx.doi.org/10.5812/traumamon.27360
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author Taghva, Alexander
Silvetz, Robert
Ring, Alex
Kim, Keun-young A.
Murphy, Kevin T.
Liu, Charles Y.
Jin, Yi
author_facet Taghva, Alexander
Silvetz, Robert
Ring, Alex
Kim, Keun-young A.
Murphy, Kevin T.
Liu, Charles Y.
Jin, Yi
author_sort Taghva, Alexander
collection PubMed
description BACKGROUND: Posttraumatic stress disorder (PTSD) is a disabling and prevalent psychiatric disorder with limited effective treatment options. In addition to the clinical features of the disease, pathologic changes in the electroencephalogram (EEG), including decreased alpha power, have been reported. OBJECTIVES: To determine if magnetic brain stimulation can induce normalization of EEG abnormalities and improve clinical symptoms in PTSD in a preliminary, open-label evaluation. MATERIALS AND METHODS: We reviewed prospectively-collected data on 21 veterans that were consecutively-treated for PTSD. Magnetic resonance therapy (MRT) was administered for two weeks at treatment frequencies based on frequency-domain analysis of each patient’s dominant alpha-band EEG frequencies and resting heart rate. Patients were evaluated on the PTSD checklist (PCL-M) and pre- and post-treatment EEGs before and after MRT. RESULTS: Of the 21 patients who initiated therapy, 16 completed treatment. Clinical improvements on the PCL-M were seen in these 16 patients, with an average pre-treatment score of 54.9 and post-treatment score of 31.8 (P < 0.001). In addition, relative global EEG alpha-band (8 - 13 Hz) power increased from 32.0 to 38.5 percent (P = 0.013), and EEG delta-band (1 - 4 Hz) power decreased from 32.3 percent to 26.8 percent (P = 0.028). CONCLUSIONS: These open-label data show trends toward normalization of EEG and concomitant clinical improvement using magnetic stimulation for PTSD.
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spelling pubmed-47274732016-02-02 Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder Taghva, Alexander Silvetz, Robert Ring, Alex Kim, Keun-young A. Murphy, Kevin T. Liu, Charles Y. Jin, Yi Trauma Mon Brief Report BACKGROUND: Posttraumatic stress disorder (PTSD) is a disabling and prevalent psychiatric disorder with limited effective treatment options. In addition to the clinical features of the disease, pathologic changes in the electroencephalogram (EEG), including decreased alpha power, have been reported. OBJECTIVES: To determine if magnetic brain stimulation can induce normalization of EEG abnormalities and improve clinical symptoms in PTSD in a preliminary, open-label evaluation. MATERIALS AND METHODS: We reviewed prospectively-collected data on 21 veterans that were consecutively-treated for PTSD. Magnetic resonance therapy (MRT) was administered for two weeks at treatment frequencies based on frequency-domain analysis of each patient’s dominant alpha-band EEG frequencies and resting heart rate. Patients were evaluated on the PTSD checklist (PCL-M) and pre- and post-treatment EEGs before and after MRT. RESULTS: Of the 21 patients who initiated therapy, 16 completed treatment. Clinical improvements on the PCL-M were seen in these 16 patients, with an average pre-treatment score of 54.9 and post-treatment score of 31.8 (P < 0.001). In addition, relative global EEG alpha-band (8 - 13 Hz) power increased from 32.0 to 38.5 percent (P = 0.013), and EEG delta-band (1 - 4 Hz) power decreased from 32.3 percent to 26.8 percent (P = 0.028). CONCLUSIONS: These open-label data show trends toward normalization of EEG and concomitant clinical improvement using magnetic stimulation for PTSD. Kowsar 2015-11-23 2015-11 /pmc/articles/PMC4727473/ /pubmed/26839865 http://dx.doi.org/10.5812/traumamon.27360 Text en Copyright © 2015, Trauma Monthly. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Brief Report
Taghva, Alexander
Silvetz, Robert
Ring, Alex
Kim, Keun-young A.
Murphy, Kevin T.
Liu, Charles Y.
Jin, Yi
Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title_full Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title_fullStr Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title_full_unstemmed Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title_short Magnetic Resonance Therapy Improves Clinical Phenotype and EEG Alpha Power in Posttraumatic Stress Disorder
title_sort magnetic resonance therapy improves clinical phenotype and eeg alpha power in posttraumatic stress disorder
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727473/
https://www.ncbi.nlm.nih.gov/pubmed/26839865
http://dx.doi.org/10.5812/traumamon.27360
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