MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice

Development of novel more efficient preventive vaccines against tuberculosis (TB) is crucial to achieve TB eradication by 2050, one of the Millennium Development Goals (MDG) for the current century. MTBVAC is the first and only live attenuated vaccine based on a human isolate of Mycobacterium tuberc...

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Detalles Bibliográficos
Autores principales: Aguilo, Nacho, Uranga, Santiago, Marinova, Dessislava, Monzon, Marta, Badiola, Juan, Martin, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Churchill Livingstone 2016
Materias:
Model Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727503/
https://www.ncbi.nlm.nih.gov/pubmed/26786657
http://dx.doi.org/10.1016/j.tube.2015.10.010
Descripción
Sumario:Development of novel more efficient preventive vaccines against tuberculosis (TB) is crucial to achieve TB eradication by 2050, one of the Millennium Development Goals (MDG) for the current century. MTBVAC is the first and only live attenuated vaccine based on a human isolate of Mycobacterium tuberculosis developed as BCG-replacement strategy in newborns that has entered first-in-human adult clinical trials. In this work, we characterize the safety, immunogenicity and protective efficacy of MTBVAC in a model of newborn C57/BL6 mice. Our data clearly indicate that MTBVAC is safe for newborn mice, and does not affect animal growth or organ development. In addition, MTBVAC-vaccinated mice at birth showed enhanced immunogenicity and better protection against M. tuberculosis challenge in comparison with BCG.

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