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Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

OBJECTIVE: Recent literature reports that radical hysterectomy followed by adjuvant radiotherapy has comparable progression-free survival and overall survival compared to radical radiotherapy for International Federation of Gynecology and Obstetrics stage IIB cervical cancer. Now, we evaluate the co...

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Autores principales: Chai, Yanlan, Wang, Juan, Wang, Tao, Shi, Fan, Wang, Jiquan, Su, Jin, Yang, Yunyi, Zhou, Xi, Ma, Hailin, He, Bin, Liu, Zi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727512/
https://www.ncbi.nlm.nih.gov/pubmed/26855584
http://dx.doi.org/10.2147/OTT.S90798
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author Chai, Yanlan
Wang, Juan
Wang, Tao
Shi, Fan
Wang, Jiquan
Su, Jin
Yang, Yunyi
Zhou, Xi
Ma, Hailin
He, Bin
Liu, Zi
author_facet Chai, Yanlan
Wang, Juan
Wang, Tao
Shi, Fan
Wang, Jiquan
Su, Jin
Yang, Yunyi
Zhou, Xi
Ma, Hailin
He, Bin
Liu, Zi
author_sort Chai, Yanlan
collection PubMed
description OBJECTIVE: Recent literature reports that radical hysterectomy followed by adjuvant radiotherapy has comparable progression-free survival and overall survival compared to radical radiotherapy for International Federation of Gynecology and Obstetrics stage IIB cervical cancer. Now, we evaluate the cost-effectiveness (CE) of these two treatment regimens. PRIMARY AND SECONDARY OUTCOME MEASURES: A decision-tree model was constructed comparing CE between treatment arms using the published studies for overall survival rates and treatment-related toxicity rates for 5 years. The cost data were obtained from the hospital system of the First Affiliated Hospital of Xi’an Jiaotong University. Effectiveness was measured as quality-adjusted life year (QALY). Treatment arms were compared with regard to costs and life expectancy using incremental CE ratio, and the results were presented using costs per QALY. RESULTS: The mean cost was $10,872 for radical hysterectomy followed by adjuvant radiotherapy versus $5,702 for radical radiotherapy. The incremental CE ratio for surgery-based treatment compared to radiotherapy-based treatment was –$76,453 per QALY. CONCLUSION: Radical radiotherapy would be a cost-effective method for FIGO stage IIB cervical cancer and would be favored in settings where resources are limited.
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spelling pubmed-47275122016-02-05 Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer Chai, Yanlan Wang, Juan Wang, Tao Shi, Fan Wang, Jiquan Su, Jin Yang, Yunyi Zhou, Xi Ma, Hailin He, Bin Liu, Zi Onco Targets Ther Original Research OBJECTIVE: Recent literature reports that radical hysterectomy followed by adjuvant radiotherapy has comparable progression-free survival and overall survival compared to radical radiotherapy for International Federation of Gynecology and Obstetrics stage IIB cervical cancer. Now, we evaluate the cost-effectiveness (CE) of these two treatment regimens. PRIMARY AND SECONDARY OUTCOME MEASURES: A decision-tree model was constructed comparing CE between treatment arms using the published studies for overall survival rates and treatment-related toxicity rates for 5 years. The cost data were obtained from the hospital system of the First Affiliated Hospital of Xi’an Jiaotong University. Effectiveness was measured as quality-adjusted life year (QALY). Treatment arms were compared with regard to costs and life expectancy using incremental CE ratio, and the results were presented using costs per QALY. RESULTS: The mean cost was $10,872 for radical hysterectomy followed by adjuvant radiotherapy versus $5,702 for radical radiotherapy. The incremental CE ratio for surgery-based treatment compared to radiotherapy-based treatment was –$76,453 per QALY. CONCLUSION: Radical radiotherapy would be a cost-effective method for FIGO stage IIB cervical cancer and would be favored in settings where resources are limited. Dove Medical Press 2016-01-19 /pmc/articles/PMC4727512/ /pubmed/26855584 http://dx.doi.org/10.2147/OTT.S90798 Text en © 2016 Chai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Chai, Yanlan
Wang, Juan
Wang, Tao
Shi, Fan
Wang, Jiquan
Su, Jin
Yang, Yunyi
Zhou, Xi
Ma, Hailin
He, Bin
Liu, Zi
Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title_full Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title_fullStr Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title_full_unstemmed Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title_short Cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer
title_sort cost-effectiveness of radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for figo stage iib cervical cancer
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727512/
https://www.ncbi.nlm.nih.gov/pubmed/26855584
http://dx.doi.org/10.2147/OTT.S90798
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