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Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector
Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727597/ https://www.ncbi.nlm.nih.gov/pubmed/26574480 http://dx.doi.org/10.1042/CS20150385 |
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author | Xu, Jing Li, Pei-Xue Wu, Jun Gao, Yi-Jun Yin, Meng-Xin Lin, Ye Yang, Ming Chen, Dong-Ping Sun, Hai-Peng Liu, Zeng-Bo Gu, Xiang-Chen Huang, Hong-Ling Fu, Li-Li Hu, Hui-Min He, Liang-Liang Wu, Wen-Qing Fei, Zhao-Liang Ji, Hong-Bin Zhang, Lei Mei, Chang-Lin |
author_facet | Xu, Jing Li, Pei-Xue Wu, Jun Gao, Yi-Jun Yin, Meng-Xin Lin, Ye Yang, Ming Chen, Dong-Ping Sun, Hai-Peng Liu, Zeng-Bo Gu, Xiang-Chen Huang, Hong-Ling Fu, Li-Li Hu, Hui-Min He, Liang-Liang Wu, Wen-Qing Fei, Zhao-Liang Ji, Hong-Bin Zhang, Lei Mei, Chang-Lin |
author_sort | Xu, Jing |
collection | PubMed |
description | Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway components were evaluated in complete/incomplete repair of I/R (ischaemia/reperfusion) AKI rat models, HK-2 cells and AKI human renal biopsy samples. We found that the expression levels of the Hippo pathway components changed dynamically during kidney regeneration and fibrogenesis in rat models of I/R-induced AKI and human renal biopsy samples. The transcription cofactor YAP (Yes-associated protein) might be a key effector of renal regeneration and fibrogenesis. Our results showed further that YAP might elicit both beneficial and detrimental effects on I/R AKI. After I/R injury occurred, YAP could promote the repair of the injured epithelia. The constant YAP increase and activation might be related to interstitial fibrosis and abnormal renal tubule differentiation. These results indicate that the proper modulation of the Hippo pathway, specifically the transcription cofactor YAP, during repair might be a potent therapeutic target in AKI–CKD transition after I/R injury. |
format | Online Article Text |
id | pubmed-4727597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47275972016-01-27 Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector Xu, Jing Li, Pei-Xue Wu, Jun Gao, Yi-Jun Yin, Meng-Xin Lin, Ye Yang, Ming Chen, Dong-Ping Sun, Hai-Peng Liu, Zeng-Bo Gu, Xiang-Chen Huang, Hong-Ling Fu, Li-Li Hu, Hui-Min He, Liang-Liang Wu, Wen-Qing Fei, Zhao-Liang Ji, Hong-Bin Zhang, Lei Mei, Chang-Lin Clin Sci (Lond) Original Papers Renal tubule cells can recover after they undergo AKI (acute kidney injury). An incomplete repair of renal tubules can result in progressive fibrotic CKD (chronic kidney disease). Studies have revealed the relationship between tubular epithelial cells and kidney fibrogenesis. However, the underlying mechanism remains unclear. Hippo pathway components were evaluated in complete/incomplete repair of I/R (ischaemia/reperfusion) AKI rat models, HK-2 cells and AKI human renal biopsy samples. We found that the expression levels of the Hippo pathway components changed dynamically during kidney regeneration and fibrogenesis in rat models of I/R-induced AKI and human renal biopsy samples. The transcription cofactor YAP (Yes-associated protein) might be a key effector of renal regeneration and fibrogenesis. Our results showed further that YAP might elicit both beneficial and detrimental effects on I/R AKI. After I/R injury occurred, YAP could promote the repair of the injured epithelia. The constant YAP increase and activation might be related to interstitial fibrosis and abnormal renal tubule differentiation. These results indicate that the proper modulation of the Hippo pathway, specifically the transcription cofactor YAP, during repair might be a potent therapeutic target in AKI–CKD transition after I/R injury. Portland Press Ltd. 2016-01-26 2016-03-01 /pmc/articles/PMC4727597/ /pubmed/26574480 http://dx.doi.org/10.1042/CS20150385 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/3.0/ This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) |
spellingShingle | Original Papers Xu, Jing Li, Pei-Xue Wu, Jun Gao, Yi-Jun Yin, Meng-Xin Lin, Ye Yang, Ming Chen, Dong-Ping Sun, Hai-Peng Liu, Zeng-Bo Gu, Xiang-Chen Huang, Hong-Ling Fu, Li-Li Hu, Hui-Min He, Liang-Liang Wu, Wen-Qing Fei, Zhao-Liang Ji, Hong-Bin Zhang, Lei Mei, Chang-Lin Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title | Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title_full | Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title_fullStr | Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title_full_unstemmed | Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title_short | Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector |
title_sort | involvement of the hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: yap is the key effector |
topic | Original Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727597/ https://www.ncbi.nlm.nih.gov/pubmed/26574480 http://dx.doi.org/10.1042/CS20150385 |
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