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The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey

OBJECTIVE: To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. METHODS: This prospective, cross-sectional, case controlled study was carried out betwee...

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Autores principales: Halac, Gulistan, Sezer, Gulsen M., Saglam, Neslihan O., Tekturk, Pinar, Demir, Aysegul D., Demir, Saliha, Akcay, Faruk, Uslu, Aysegul, Yapıcı, Zuhal, Asil, Talip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Riyadh : Armed Forces Hospital 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727615/
https://www.ncbi.nlm.nih.gov/pubmed/26492111
http://dx.doi.org/10.17712/nsj.2015.4.20150268
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author Halac, Gulistan
Sezer, Gulsen M.
Saglam, Neslihan O.
Tekturk, Pinar
Demir, Aysegul D.
Demir, Saliha
Akcay, Faruk
Uslu, Aysegul
Yapıcı, Zuhal
Asil, Talip
author_facet Halac, Gulistan
Sezer, Gulsen M.
Saglam, Neslihan O.
Tekturk, Pinar
Demir, Aysegul D.
Demir, Saliha
Akcay, Faruk
Uslu, Aysegul
Yapıcı, Zuhal
Asil, Talip
author_sort Halac, Gulistan
collection PubMed
description OBJECTIVE: To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. METHODS: This prospective, cross-sectional, case controlled study was carried out between January and June 2013, and included 98 iron deficiency and/or iron deficiency anemia, and 102 healthy children referred to the Neurology and Pediatric Departments of the Medical Faculty of Bezmialem Vakif University, Istanbul, Turkey. Both groups were evaluated according to the International Restless Legs Syndrome Study Group diagnostic criteria. RESULTS: The range of ferritin levels was 0.01-12 mg/ml in patients while it was 12.3-91.8 mg/mL in the control group. Restless legs syndrome was detected in 61.2% of children with iron deficiency anemia, and in 37.3% of children with normal biochemistry values. A statistically significant correlation was found between serum ferritin levels and frequency of RLS. In patients with serum ferritin levels higher than 50 ng/ml, 92.3% had no RLS, while 55.2% of patients with serum ferritin levels lower than 50ng/ml had RLS. The patients with serum ferritin levels of >50ng/ml had a significantly higher incidence of RLS. Serum ferritin levels were significantly different between the 2 groups. CONCLUSION: The incidence of RLS, also known as Willis-Ekbom Disease, is high in children aged between 8-18 years with iron deficiency, or iron deficiency anemia, or both. This finding supports the importance of iron replacement therapy especially during the growth and development of children.
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spelling pubmed-47276152016-02-02 The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey Halac, Gulistan Sezer, Gulsen M. Saglam, Neslihan O. Tekturk, Pinar Demir, Aysegul D. Demir, Saliha Akcay, Faruk Uslu, Aysegul Yapıcı, Zuhal Asil, Talip Neurosciences (Riyadh) Original Articles OBJECTIVE: To examine the incidence of restless legs syndrome (RLS) among children with iron deficiency, or iron deficiency anemia, or both, and the relationship between RLS prevalence and serum ferritin levels. METHODS: This prospective, cross-sectional, case controlled study was carried out between January and June 2013, and included 98 iron deficiency and/or iron deficiency anemia, and 102 healthy children referred to the Neurology and Pediatric Departments of the Medical Faculty of Bezmialem Vakif University, Istanbul, Turkey. Both groups were evaluated according to the International Restless Legs Syndrome Study Group diagnostic criteria. RESULTS: The range of ferritin levels was 0.01-12 mg/ml in patients while it was 12.3-91.8 mg/mL in the control group. Restless legs syndrome was detected in 61.2% of children with iron deficiency anemia, and in 37.3% of children with normal biochemistry values. A statistically significant correlation was found between serum ferritin levels and frequency of RLS. In patients with serum ferritin levels higher than 50 ng/ml, 92.3% had no RLS, while 55.2% of patients with serum ferritin levels lower than 50ng/ml had RLS. The patients with serum ferritin levels of >50ng/ml had a significantly higher incidence of RLS. Serum ferritin levels were significantly different between the 2 groups. CONCLUSION: The incidence of RLS, also known as Willis-Ekbom Disease, is high in children aged between 8-18 years with iron deficiency, or iron deficiency anemia, or both. This finding supports the importance of iron replacement therapy especially during the growth and development of children. Riyadh : Armed Forces Hospital 2015-10 /pmc/articles/PMC4727615/ /pubmed/26492111 http://dx.doi.org/10.17712/nsj.2015.4.20150268 Text en Copyright: © Neurosciences https://creativecommons.org/licenses/by-nc-sa/3.0/Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.
spellingShingle Original Articles
Halac, Gulistan
Sezer, Gulsen M.
Saglam, Neslihan O.
Tekturk, Pinar
Demir, Aysegul D.
Demir, Saliha
Akcay, Faruk
Uslu, Aysegul
Yapıcı, Zuhal
Asil, Talip
The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title_full The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title_fullStr The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title_full_unstemmed The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title_short The relationship between Willis-Ekbom disease and serum ferritin levels among children in Northwestern Turkey
title_sort relationship between willis-ekbom disease and serum ferritin levels among children in northwestern turkey
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727615/
https://www.ncbi.nlm.nih.gov/pubmed/26492111
http://dx.doi.org/10.17712/nsj.2015.4.20150268
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