A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil

Drug product purity and potency are of most significance in the regulatory market as we notice many recalled batches worldwide, particularly in the US and Japan. Olmesartan Medoxomil is an anti-hypertensive drug. The present invention relates to a process for the preparation of Olmesartan Medoxomil...

Descripción completa

Detalles Bibliográficos
Autores principales: Hanumantha Rao, Bommena, Subramanyeswara Rao, Inti Venkata, Ravi Kanth, Vysyaraju, Prasada Rao, Korrapati Venkata Vara, Balamurali Krishna, K., Syama Sundar, Bethanabatla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727774/
https://www.ncbi.nlm.nih.gov/pubmed/26839831
http://dx.doi.org/10.3797/scipharm.1502-04
_version_ 1782412019776880640
author Hanumantha Rao, Bommena
Subramanyeswara Rao, Inti Venkata
Ravi Kanth, Vysyaraju
Prasada Rao, Korrapati Venkata Vara
Balamurali Krishna, K.
Syama Sundar, Bethanabatla
author_facet Hanumantha Rao, Bommena
Subramanyeswara Rao, Inti Venkata
Ravi Kanth, Vysyaraju
Prasada Rao, Korrapati Venkata Vara
Balamurali Krishna, K.
Syama Sundar, Bethanabatla
author_sort Hanumantha Rao, Bommena
collection PubMed
description Drug product purity and potency are of most significance in the regulatory market as we notice many recalled batches worldwide, particularly in the US and Japan. Olmesartan Medoxomil is an anti-hypertensive drug. The present invention relates to a process for the preparation of Olmesartan Medoxomil with 99.9% purity in an overall 62% yield. The synthesis includes three isolations and one purification with easy plant operations. This process describes the formation and control of each individual impurity in all stages. This process for Olmesartan Medoxomil and its intermediates is competent for industrial production in very short reaction time intervals with an appreciable yield and high purity.
format Online
Article
Text
id pubmed-4727774
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Austrian Journal of Pharmaceutical Sciences
record_format MEDLINE/PubMed
spelling pubmed-47277742016-02-02 A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil Hanumantha Rao, Bommena Subramanyeswara Rao, Inti Venkata Ravi Kanth, Vysyaraju Prasada Rao, Korrapati Venkata Vara Balamurali Krishna, K. Syama Sundar, Bethanabatla Sci Pharm Research Article Drug product purity and potency are of most significance in the regulatory market as we notice many recalled batches worldwide, particularly in the US and Japan. Olmesartan Medoxomil is an anti-hypertensive drug. The present invention relates to a process for the preparation of Olmesartan Medoxomil with 99.9% purity in an overall 62% yield. The synthesis includes three isolations and one purification with easy plant operations. This process describes the formation and control of each individual impurity in all stages. This process for Olmesartan Medoxomil and its intermediates is competent for industrial production in very short reaction time intervals with an appreciable yield and high purity. The Austrian Journal of Pharmaceutical Sciences 2015 2015-03-31 /pmc/articles/PMC4727774/ /pubmed/26839831 http://dx.doi.org/10.3797/scipharm.1502-04 Text en Copyright: © Sasmito et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hanumantha Rao, Bommena
Subramanyeswara Rao, Inti Venkata
Ravi Kanth, Vysyaraju
Prasada Rao, Korrapati Venkata Vara
Balamurali Krishna, K.
Syama Sundar, Bethanabatla
A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title_full A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title_fullStr A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title_full_unstemmed A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title_short A Competent and Commercially Viable Process for the Synthesis of the Anti-Hypertensive Drug Olmesartan Medoxomil
title_sort competent and commercially viable process for the synthesis of the anti-hypertensive drug olmesartan medoxomil
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727774/
https://www.ncbi.nlm.nih.gov/pubmed/26839831
http://dx.doi.org/10.3797/scipharm.1502-04
work_keys_str_mv AT hanumantharaobommena acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT subramanyeswararaointivenkata acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT ravikanthvysyaraju acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT prasadaraokorrapativenkatavara acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT balamuralikrishnak acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT syamasundarbethanabatla acompetentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT hanumantharaobommena competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT subramanyeswararaointivenkata competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT ravikanthvysyaraju competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT prasadaraokorrapativenkatavara competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT balamuralikrishnak competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil
AT syamasundarbethanabatla competentandcommerciallyviableprocessforthesynthesisoftheantihypertensivedrugolmesartanmedoxomil

Ejemplares similares