An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir

A simple and efficient process for the preparation of (±)-9-[(2,3-dihydroxypropoxy)methyl]guanine (isoganciclovir) is described. The synthesis features the preparation of a kinetically and thermodynamically controlled acyclic side chain using masked glycerol and methoxymethyl acetate. The unwanted r...

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Detalles Bibliográficos
Autores principales: Sundaram, Dhanraj T. S. S., Kamat, Anand G., Prabahar, Koilpillai Joseph, Gupta, Peruri Badarinadh, Venkateswara Rao, Battula, Paul Douglas, Sanasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727779/
https://www.ncbi.nlm.nih.gov/pubmed/26839813
http://dx.doi.org/10.3797/scipharm.1409-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727779/
https://www.ncbi.nlm.nih.gov/pubmed/26839813
http://dx.doi.org/10.3797/scipharm.1409-15

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