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An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir
A simple and efficient process for the preparation of (±)-9-[(2,3-dihydroxypropoxy)methyl]guanine (isoganciclovir) is described. The synthesis features the preparation of a kinetically and thermodynamically controlled acyclic side chain using masked glycerol and methoxymethyl acetate. The unwanted r...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Austrian Journal of Pharmaceutical Sciences
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727779/ https://www.ncbi.nlm.nih.gov/pubmed/26839813 http://dx.doi.org/10.3797/scipharm.1409-15 |