Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Thiosulfonate derivatives based on quinones were synthesized for studying “structure-activity relationship” compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was a...

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Detalles Bibliográficos
Autores principales: Bolibrukh, Khrystyna, Polovkovych, Svyatoslav, Khoumeri, Omar, Halenova, Tetyana, Nikolaeva, Irina, Savchuk, Olexiy, Terme, Thierry, Vanelle, Patrice, Lubenets, Vira, Novikov, Volodymyr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Austrian Journal of Pharmaceutical Sciences 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727794/
https://www.ncbi.nlm.nih.gov/pubmed/26839819
http://dx.doi.org/10.3797/scipharm.1411-14
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author Bolibrukh, Khrystyna
Polovkovych, Svyatoslav
Khoumeri, Omar
Halenova, Tetyana
Nikolaeva, Irina
Savchuk, Olexiy
Terme, Thierry
Vanelle, Patrice
Lubenets, Vira
Novikov, Volodymyr
author_facet Bolibrukh, Khrystyna
Polovkovych, Svyatoslav
Khoumeri, Omar
Halenova, Tetyana
Nikolaeva, Irina
Savchuk, Olexiy
Terme, Thierry
Vanelle, Patrice
Lubenets, Vira
Novikov, Volodymyr
author_sort Bolibrukh, Khrystyna
collection PubMed
description Thiosulfonate derivatives based on quinones were synthesized for studying “structure-activity relationship” compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed.
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spelling pubmed-47277942016-02-02 Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety Bolibrukh, Khrystyna Polovkovych, Svyatoslav Khoumeri, Omar Halenova, Tetyana Nikolaeva, Irina Savchuk, Olexiy Terme, Thierry Vanelle, Patrice Lubenets, Vira Novikov, Volodymyr Sci Pharm Research Article Thiosulfonate derivatives based on quinones were synthesized for studying “structure-activity relationship” compounds with an acylated and a free amino-group. Anti-platelet activity of the synthesized compounds was determined and the influence of substituents on the activity of the derivatives was assessed. The Austrian Journal of Pharmaceutical Sciences 2015 2015-02-24 /pmc/articles/PMC4727794/ /pubmed/26839819 http://dx.doi.org/10.3797/scipharm.1411-14 Text en Copyright: © Bolibrukh et al. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bolibrukh, Khrystyna
Polovkovych, Svyatoslav
Khoumeri, Omar
Halenova, Tetyana
Nikolaeva, Irina
Savchuk, Olexiy
Terme, Thierry
Vanelle, Patrice
Lubenets, Vira
Novikov, Volodymyr
Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title_full Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title_fullStr Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title_full_unstemmed Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title_short Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety
title_sort synthesis and anti-platelet activity of thiosulfonate derivatives containing a quinone moiety
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727794/
https://www.ncbi.nlm.nih.gov/pubmed/26839819
http://dx.doi.org/10.3797/scipharm.1411-14
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